Efficacy of intraperitoneal and intravenous lidocaine on pain relief after
laparoscopic cholecystectomy.
Author(s): Yang SY(1), Kang H, Choi GJ, Shin HY, Baek CW, Jung YH, Choi YS.
Affiliation(s): Author information:
(1)Department of Anaesthesiology and Pain Medicine, College of Medicine, Chung-Ang
University, Seoul, Republic of Korea.
Publication date & source: 2014, J Int Med Res. , 42(2):307-19
OBJECTIVES: This randomized, double-blind, placebo-controlled trial evaluated
intraperitoneal (IP) lidocaine administration and intravenous (IV) lidocaine
infusion for postoperative pain control after laparoscopic cholecystectomy (LC).
METHODS: Patients who underwent LC were randomized to either group IV
(intravenous lidocaine infusion), group IP (intraperitoneal lidocaine
administration), or group C (control, IP and IV saline). Outcome measures were
total postoperative pain severity (TPPS), total fentanyl consumption (TFC),
frequency of administering patient-controlled analgesia (FPB), and a pain control
satisfaction score (PCSS).
RESULTS: Significantly reduced TPPS, TFC and FPB scores were observed in groups
IP (n = 22) and IV (n = 26) compared with controls (n = 24). PCSS was higher in
groups IP and IV than in controls. At 2 h postoperation, TPPS was significantly
lower in group IP than group IV; at 0-2 h postoperation, FPB was lower in group
IP than group IV.
CONCLUSIONS: The IP administration of lidocaine and IV lidocaine infusion
significantly reduced postoperative pain and opioid consumption in LC patients,
compared with control infusions. For convenience, IV lidocaine could be used for
pain reduction following LC; IP administration places additional burden on the
surgeon.
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