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Ineffectiveness of folic acid supplementation against phenytoin-induced decrease in salivary immunoglobulin A concentration of epileptic patients.

Author(s): Zare M, Ghazvini MR, Yazdi HR, Nezhad VS, Chitsaz A

Affiliation(s): Department of Neurology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Publication date & source: 2008, Eur Neurol., 59(6):299-301. Epub 2008 Apr 11.

Publication type: Randomized Controlled Trial; Research Support, Non-U.S. Gov't

AIMS: This study was designed to investigate if folate treatment is able to reverse the phenytoin-induced deficiency of salivary immunoglobulin A (IgA). METHODS AND MATERIAL: Twenty-five epileptic patients who had been under phenytoin therapy for at least the last 6 months were randomly selected and subjected to folic acid supplementation, 1 mg/day. The salivary IgA concentration of these patients was measured before and after 2 months of folic acid administration and compared with those of 10 healthy individuals. Independent and paired Student's t tests were used to analyze the effects of phenytoin and folic acid, respectively. RESULTS: Salivary IgA levels of patients receiving phenytoin (11.7 +/- 4.8 IU/l) were significantly (p = 0.039) lower than those of healthy controls (14.8 +/- 3.2 IU/l), but did not statistically (p = 0.541) differ from levels (11.8 +/- 4.6 IU/l) measured after 2 months of folic acid supplementation. CONCLUSIONS: According to these results, folic acid supplementation does not seem to have the efficacy to ameliorate phenytoin-induced salivary IgA hyposecretion. (c) 2008 S. Karger AG, Basel

Page last updated: 2008-06-22

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