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[Bronchofiberscope and catheter intervention in treatment of multi-drug resistant pulmonary tuberculosis]

Author(s): Zhang Y, Qian H, Chen M

Affiliation(s): Department of Pulmonary Medicine, 175th Hospital, P.L.A., Zhangzhou.

Publication date & source: 1997-12, Zhonghua Jie He He Hu Xi Za Zhi., 20(6):354-7.

Publication type: Clinical Trial; Randomized Controlled Trial

OBJECTIVE: To evaluate the clinical value of bronchofiberscope and catheter intervention in treatment of multi-drug resistant pulmonary tuberculosis. METHOD: Forty-eight patients with multi-drug resistant pulmonary tuberculosis were treated by injecting ofloxacin and amikacin through bronchofiberscope and catheter in addition to chemotherapy, while forty controls were treated by chemotherapy only. RESULT: At the end of the treatment, the sputum conversion rate was 92%, radiographic improvement rate 96% and cavity closing rate 27% in the treatment group, all of which were higher than the controls (63%, 58% and 10% respectively) (P < 0.01-0.05). No complication and obvious adverse reaction were observed. CONCLUSION: The efficacy of bronchofiberscope and catheter intervention in addition to chemotherapy is better than only chemotherapy in treatment of multi-drug resistant pulmonary tuberculosis.

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