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Active ingredient: Alprostadil - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C20H34O5

Chemical Name

7-[3-hydroxy-2-(3-hydroxyoct-1-enyl)-5-oxo-cyclopentyl]heptanoic acid

Chemical Structure

Molecular Weight

354.481 g/mol

Physical State

Solid

Melting Point

115 - 116 oC

Water Solubility

26.7 mg/L

Isoelectric Point

4.85

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
NameProstaglandin E2 receptor, EP2 subtype
Gene NamePTGER2
SynonymsProstanoid EP2 receptor; PGE receptor, EP2 subtype
Specific FunctionReceptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle

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