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Active ingredient: Amlexanox - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Anti-Allergic Agents
  • Antiulcer agent (topical)
  • Anti-inflammatory, Locally Applied

Dosage Forms

  • Oral paste (5%, 5g)

Brands / Synonyms

Amlenanox; Amlexanox [USAN:INN:JAN]; Amlexanoxo [Spanish]; Amlexanoxum [Latin]; Amoxanox; Aphthasol; Elics; Solfa

Indications

Used as a paste in the mouth to treat aphthous ulcers (canker sores).

Pharmacology

Amlexanox is a mucoadhesive oral paste which has been clinically proven to abort the onset, accelerate healing and resolve the pain of aphthous ulcers (canker sores). It decreases the time ulcers take to heal. Because amlexanox decreases the healing time, it also decreases the pain you feel. Recent studies have also shown that the majority of ulcers can be prevented by application of the paste during the prodromal (pre-ulcerative) phase of the disease. Recurrent Aphthous Ulcers (RAU) also known as Recurrent Aphthous Stomatitis (RAS) is recognized as the most common oral mucosal disease known to man. Estimates suggest that 20% - 25% of the general population suffer at least one incidence of aphthous ulcers each year.

Mechanism of Action

As a benzopyrano-bipyridine carboxylic acid derivative, amlexanox has anti-inflammatory and antiallergic properties. It inhibits chemical mediatory release of the slow-reacting substance of anaphylaxis (SRS-A) and may have antagonistic effects on interleukin-3.

Absorption

No significant absorption directly through the active ulcer. Most of the systemic absorption is via the gastrointestinal tract.

Toxicity

Not Available

Biotrnasformation / Drug Metabolism

Metabolized to hydroxylated and conjugated metabolites.

Contraindications

Hypersensitivity to amlexanox or any component of the formulation.

Drug Interactions

Not Available

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