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Active ingredient: Amphotericin B - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula


Chemical Name

3-(4-amino-3,5-dihydroxy-6-methyl-oxan-2-yl)oxy-19,25,27,30,31,33,35,37- octahydroxy-18,20,21-trimethyl-23-oxo-22,39- dioxabicyclo[33.3.1]nonatriaconta-4,6,8,10,12,14,16-heptaene-38- carboxylic acid

Chemical Structure

Molecular Weight

924.079 g/mol

Physical State


Melting Point

170.0 oC

Water Solubility

750 mg/L

Isoelectric Point

Not Available

Organisms Affected

Various Fungus Species

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
NameErgosterol biosynthetic protein 28
Gene NameERG28
Specific FunctionMay have a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum. May also be responsible for facilitating their interaction

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