Brands, Medical Use, Clinical Data
Drug Category
- Coagulants
- Thrombotic Agents
Dosage Forms
- Powder for solution
- Solution (IV injection)
Brands / Synonyms
Advate; AHF; Alphanate; Bioclate; Coagulation factor VIII precursor; Helixate; Helixate FS; Hemofil M; Humate-P; Hyate:C; Koate-DVI; Koate-HP; Kogenate; Kogenate FS; Monarc-M; Monoclate-P; Nateglinide
; Procoagulant component; Recombinate; Refacto
Description
Human recombinant antihemophilic factor (AHF) or Factor VIII, 2332 residues, glycosylated, produced by CHO cells
Indications
For the treatment of hemophilia A, von Willebrand diseae and Factor XIII deficiency
Pharmacology
Antihemophilic Factor binds factor IXa along with calcium and phospholipid, This complex converts factor X to factor Xa to facilitate clotting cascade.
Mechanism of Action
Antihemophilic factor (AHF) is a protein found in normal plasma which is necessary for clot formation. The administration of AHF provides an increase in plasma levels of AHF and can temporarily correct the coagulation defect of patients with hemophilia A (classical hemophilia).
Absorption
Not Available
Toxicity
Not Available
Biotrnasformation / Drug Metabolism
Not Available
Contraindications
Not Available
Drug Interactions
Not Available
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