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Active ingredient: Ardeparin - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Anticoagulants
  • Fibrinolytic Agents

Dosage Forms

  • Injection

Brands / Synonyms

Normiflo

Indications

For prevention of deep vein thrombosis, which may result in pulmonary embolism, following knee surgery.

Pharmacology

Ardeparin, an anticoagulant, is a fractionated heparin. It acts at multiple sites in the normal coagulation system to inhibit reactions that lead to the clotting of blood and the formation of fibrin clots both in vitro and in vivo.

Mechanism of Action

Ardeparin binds to antithrombin III, accelerating its activity and inactivating factor Xa and thrombin, thereby inhibiting thrombosis. Ardeparin also binds to heparin cofactor II, inhibiting thrombin. Ardeparin does not effect prothrombin time (PT) assays and may prolong activated partial thromboplastin time (APTT). Ardeparin has double the anti-factor Xa activity of anti-factor IIa activity, compared to unfractionated heparin which has approximately equal anti-factor Xa activity and anti-factor IIa activity.

Absorption

Well absorbed following subcutaneous administration, with a mean bioavailability of 92% (based on anti-factor Xa activity).

Toxicity

Symptoms of overdose may include excessive bleeding and bruising.

Biotrnasformation / Drug Metabolism

Liver and the reticulo-endothelial system are the sites of biotransformation.

Contraindications

Contraindicated in active bleeding (can exacerbate bleeding), hypertension (can increase the risk of cerebral hemorrhage), and hemorrhagic stroke (can increase the risk of uncontrollable hemorrhage).

Drug Interactions

Anticoagulants including coumarin derivatives, indandione derivatives, and platelet aggregation inhibitors such as nonsteroidal anti-inflammatory drugs (NSAIDs), and aspirin may increase the risk of bleeding when administered concomitantly with ardeparin.

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