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Active ingredient: Bevacizumab - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

Not Available

Chemical Name

Humanized anti-VEGF antibody

Chemical Structure NA

Molecular Weight

Not Available

Physical State

Liquid

Melting Point

61 oC (FAB fragment), 71 oC (whole mAb) - Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000).

Water Solubility

Not Available

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
NameVascular endothelial growth factor
Gene NameVEGF
SynonymsVascular endothelial growth factor A precursor; VEGF-A; Vascular permeability factor; VPF
Specific FunctionGrowth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Binds to the VEGFR1/Flt-1 and VEGFR2/Kdr receptors, heparan sulfate and heparin. Neuropilin-1 binds isoforms VEGF-165 and VEGF-145

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