Chemisty and Biological Activity
Chemical Formula
C27H29N5O6S
Chemical Name
N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4- yl]-4-tert-butyl-benzenesulfonamide
Chemical Structure
Molecular Weight
551.615 g/mol
Physical State
Solid
Melting Point
Not Available
Water Solubility
Poorly soluble in water (1.0 mg/100 ml) and in aqueous solutions at low pH (0.1 mg/100 ml at pH 1.1 and 4.0; 0.2 mg/100 ml at pH 5.0). Solubility increases at higher pH values (43 mg/100 ml at pH 7.5).
Isoelectric Point
Not Available
Organisms Affected
Humans and other mammals
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
CYP3A4; CYP2C9
Primary Drug Target
Name | Endothelin B receptor precursor | Gene Name | EDNRB | Synonyms | ET-B; Endothelin receptor Non- selective type | Specific Function | Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system |
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