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Active ingredient: Buspirone - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C21H31N5O2

Chemical Name

8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9- dione

Chemical Structure

Molecular Weight

385.503 g/mol

Physical State

Solid

Melting Point

201.5-202.5oC

Water Solubility

21.4 mg/L

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

CYP3A4

Primary Drug Target
Name5-HT-1A Receptor
Gene NameHTR1A
Synonyms5-hydroxytryptamine 1A receptor; 5-HT-1A; Serotonin receptor 1A; 5- HT1A; G-21
General FunctionSignal transduction and cell communication
Specific FunctionThis is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity

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