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Active ingredient: Chlorthalidone - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C14H11ClN2O4S

Chemical Name

2-chloro-5-(1-hydroxy-3-oxo-1,2-dihydroisoindol-1-yl)-benzenesulfonamide

Chemical Structure

Molecular Weight

338.767 g/mol

Physical State

Solid

Melting Point

218-264oC

Water Solubility

120 mg/L

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
NameNa+/K+/2Cl- co-transporter
Gene NameSLC12A1
SynonymsSolute carrier family 12, member 1; Bumetanide-sensitive sodium-; Potassium-chloride cotransporter 2; Kidney-specific Na-K-Cl symporter
Specific FunctionElectrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.

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