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Active ingredient: Codeine - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C18H21NO3

Chemical Name

(5(,6()-7,8-didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol

Chemical Structure

Molecular Weight

299.364 g/mol

Physical State

solid

Melting Point

154 - 156 oC

Water Solubility

<0.1 g/100 mL

Isoelectric Point

8.21

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

CYP2D6

Primary Drug Target
NameOpioid mu Receptor (OP3)
Gene NameOPRM1
SynonymsMu-type opioid receptor; MOR-1
Specific FunctionInhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for beta-endorphin.

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