Brands, Medical Use, Clinical Data
Drug Category
- Immunmodulatory Agents
- Immunosupressants
Dosage Forms
- Capsule (liquid-filled)
- Capsule (liquid-filled for emulsion)
- Solution (oral)
- Solution (IV infusion)
Brands / Synonyms
Gengraf; Gengraf (Abbott labs); Neoral; Neoral (Novartis); Restasis; Restasis (Allergan Inc); Sandimmune; Sandimmune (Novartis)
Description
11 amino acid cyclic peptide. It is produced as a metabolite by the fungus species Beauveria nlyea.
Indications
For treatment of transplant rejection, rheumatoid arthritis, severe psoriasis
Pharmacology
Used in immunosuppression for prophylactic treatment of organ transplants, cyclosporine exerts specific and reversible inhibition of immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited. The T1-helper cell is the main target, although the T1-suppressor cell may also be suppressed. Sandimmune (cyclosporine) also inhibits lymphokine production and release including interleukin-2.
Mechanism of Action
Cyclosporine binds to cyclophillin. The complex then inhibits calcineurin which is normally responsible for activating transcription of interleukin 2. Cyclosporine also inhibits lymphokine production and ineterluekin relase.
Absorption
Not Available
Toxicity
Not Available
Biotrnasformation / Drug Metabolism
Not Available
Contraindications
Not Available
Drug Interactions
Not Available
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