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Active ingredient: Dimenhydrinate - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Antiemetics
  • Histamine H1 Antagonists

Dosage Forms

  • Capsule (sustained-release)
  • Liquid
  • Solution
  • Suppository
  • Syrup
  • Tablet
  • Tablet (extended-release)

Brands / Synonyms

Amosyt; Anautine; Andramine; Antemin; Aviomarin; Chloranautine; Diamarin; Dimate; Dimenest; Dimenhydrinate; Dimentabs; Diphenhydramine Theoclate; Diphenhydrinate; Dramalen; Dramamin; Dramamine; Dramarin; Dramilin; Dramyl; Dromyl; Eldodram; Gravinol; Gravol; Hydrinate; Menhydrinate; Neo-Navigan; Novamine; Permital; Reise-Engletten; Supremal; Teodramin; Travelin; Travelmin; Troversin; Vomex A; Xamamina


Used for treating vertigo, motion sickness, and nausea associated with pregnancy.


Dimenhydrinate is an antiemetics drug combination that contains diphenhydramine and theophylline. It is not effective in the treatment of nausea associated with cancer chemotherapy. Dimenhydrinate directly inhibits the stimulation of certain nerves in the brain and inner ear to suppress nausea, vomiting, dizziness, and vertigo.

Mechanism of Action

The mechanism by which some antihistamines exert their antiemetic, anti–motion sickness, and antivertigo effects is not precisely known but may be related to their central anticholinergic actions. They diminish vestibular stimulation and depress labyrinthine function. An action on the medullary chemoreceptive trigger zone may also be involved in the antiemetic effect.


Well absorbed after oral administration.


Symptoms of overdose include delerium and hallucinations.

Biotrnasformation / Drug Metabolism

Hepatic (cytochrome P-450 system).


Dimenhydrinate may impede diagnosis of appendicitis and may obscure signs of overdose.

Drug Interactions

Dimenhydrinate may decrease emetic response to apomorphine.

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