Brands, Medical Use, Clinical Data
Drug Category
- Antiemetics
- Histamine H1 Antagonists
Dosage Forms
- Capsule (sustained-release)
- Liquid
- Solution
- Suppository
- Syrup
- Tablet
- Tablet (extended-release)
Brands / Synonyms
Amosyt; Anautine; Andramine; Antemin; Aviomarin; Chloranautine; Diamarin; Dimate; Dimenest; Dimenhydrinate; Dimentabs; Diphenhydramine Theoclate; Diphenhydrinate; Dramalen; Dramamin; Dramamine; Dramarin; Dramilin; Dramyl; Dromyl; Eldodram; Gravinol; Gravol; Hydrinate; Menhydrinate; Neo-Navigan; Novamine; Permital; Reise-Engletten; Supremal; Teodramin; Travelin; Travelmin; Troversin; Vomex A; Xamamina
Indications
Used for treating vertigo, motion sickness, and nausea associated with pregnancy.
Pharmacology
Dimenhydrinate is an antiemetics drug combination that contains diphenhydramine and theophylline. It is not effective in the treatment of nausea associated with cancer chemotherapy. Dimenhydrinate directly inhibits the stimulation of certain nerves in the brain and inner ear to suppress nausea, vomiting, dizziness, and vertigo.
Mechanism of Action
The mechanism by which some antihistamines exert their antiemetic, anti–motion sickness, and antivertigo effects is not precisely known but may be related to their central anticholinergic actions. They diminish vestibular stimulation and depress labyrinthine function. An action on the medullary chemoreceptive trigger zone may also be involved in the antiemetic effect.
Absorption
Well absorbed after oral administration.
Toxicity
Symptoms of overdose include delerium and hallucinations.
Biotrnasformation / Drug Metabolism
Hepatic (cytochrome P-450 system).
Contraindications
Dimenhydrinate may impede diagnosis of appendicitis and may obscure signs of overdose.
Drug Interactions
Dimenhydrinate may decrease emetic response to apomorphine.
|
