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Active ingredient: Donepezil - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C24H29NO3

Chemical Name

2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one

Chemical Structure

Molecular Weight

379.492 g/mol

Physical State

Solid

Melting Point

206.72 oC

Water Solubility

2.931 mg/L

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

CYP3A4; CYP2D6

Primary Drug Target
NameAcetylcholinesterase (AChE)
Gene NameACHE
SynonymsAcetylcholinesterase precursor; EC 3.1.1.7; AChE
General FunctionLipid transport and metabolism
Specific FunctionRapidly hydrolyzes choline released into the synapse
Pathwaymap00564 Glycerophospholipid metabolism
Reactionacetylcholine + H2O = choline + acetate

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