Chemisty and Biological Activity
Chemical Formula
C20H28N2O5
Chemical Name
1-[2-(1-ethoxycarbonyl-3-phenyl-propyl)aminopropanoyl]pyrrolidine-2- carboxylic acid
Chemical Structure
Molecular Weight
376.447 g/mol
Physical State
Solid
Melting Point
143-144.5oC
Water Solubility
0.025g/mL
Isoelectric Point
Not Available
Organisms Affected
Humans and other mammals
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
CYP3A4
Primary Drug Target
Name | Angiotensin-converting enzyme (ACE) | Gene Name | ACE | Synonyms | Angiotensin-converting enzyme, testis-specific isoform precursor; EC 3.4.15.1; ACE-T; Dipeptidyl carboxypeptidase I; Kininase II | Specific Function | Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator | Reaction | Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II |
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