Brands, Medical Use, Clinical Data
Drug Category
Dosage Forms
Brands / Synonyms
Epoetin; Epogen; Epogen (Amgen Inc.); Epogin (Chugai); Epomax (Elanex); Eprex (Janssen-Cilag. Ortho Biologics LLC); Erythropoietin precursor; NeoRecormon (Roche); Procrit; Procrit (Ortho Biotech); Recormon (Roche)
Description
Human erythropoietin (recombinant), produced by CHO cells.
Indications
For treatment of anemia (from renal transplants or certain HIV treatment)
Pharmacology
Used in the treatment of anemia. Involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.
Mechanism of Action
Binding of erythropoietin to the erythropoietin receptor leads to receptor dimerization, which facilitates activation of JAK-STAT signaling pathways within the cytosol. Activated STAT (signal transducers and activators of transcription) proteins are then translocated to the nucleus where they serve as transcription factors which regulate the activation of specific genes involved in cell division or differentiation.
Absorption
Not Available
Toxicity
Not Available
Biotrnasformation / Drug Metabolism
Not Available
Contraindications
Not Available
Drug Interactions
Not Available
|
