Chemisty and Biological Activity
Chemical Formula
C22H25N3O7S
Chemical Name
3-[5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl]sulfanyl-7-(1- hydroxyethyl)-2-methyl-6-oxo-5-azabicyclo[3.2.0]hept-3-ene-4- carboxylic acid
Chemical Structure
Molecular Weight
475.516 g/mol
Physical State
Solid
Melting Point
Not Available
Water Solubility
Soluble as sodium salt
Isoelectric Point
Not Available
Organisms Affected
Enteric bacteria and other eubacteria
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
Not Available
Primary Drug Target
| Name | Penicillin-binding protein 1B | | Gene Name | mrcB | | Synonyms | PBP-1b; PBP1b; Murein polymerase[Includes: Penicillin-insensitive transglycosylase; EC 2.4.1.129; Peptidoglycan glycosyltransferase; Peptidoglycan TGase; Penicillin- sensitive transpeptidase; EC 3.4.-.-; DD-transpeptidase] | | General Function | Cell wall/membrane/envelope biogenesis | | Specific Function | Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) | | Pathway | map00550 Peptidoglycan biosynthesis | | Reaction | [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n- $diphosphoundecaprenol + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu- $L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = [GlcNAc-(1->4)- $Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n+1- $diphosphoundecaprenol + undecaprenyl diphosphate |
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