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Active ingredient: Fludarabine - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Immunosuppressive Agents
  • Antimetabolites
  • Antineoplastic Agents

Dosage Forms

  • Tablet
  • Powder for solution
  • IV solution

Brands / Synonyms

FAMP; Fludara; Fludarabine 5'-monophosphate; Fludarabine monophosphate; Fludarabine phosphate; Fludarabine phosphate [Usan:Ban]; Fludura

Indications

For the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen

Pharmacology

Fludarabine is a chemotherapy drug used in the treatment of chronic lymphocytic leukemia. It acts at DNA polymerase alpha, ribonucleotide reductase and DNA primase, results in the inhibition of DNA synthesis, and destroys the cancer cells.

Mechanism of Action

Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. The mechanism of action of this antimetabolite is not completely characterized and may be multi-faceted.

Absorption

Not Available

Toxicity

Not Available

Biotrnasformation / Drug Metabolism

Not Available

Contraindications

FLUDARA FOR INJECTION is contraindicated in those patients who are hypersensitive to this drug or its components.

Drug Interactions

The use of FLUDARA FOR INJECTION in combination with pentostatin is not recommended due to the risk of severe pulmonary toxicity.

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