Brands, Medical Use, Clinical Data
Drug Category
- Immunosuppressive Agents
- Antimetabolites
- Antineoplastic Agents
Dosage Forms
- Tablet
- Powder for solution
- IV solution
Brands / Synonyms
FAMP; Fludara; Fludarabine 5'-monophosphate; Fludarabine monophosphate; Fludarabine phosphate; Fludarabine phosphate [Usan:Ban]; Fludura
Indications
For the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen
Pharmacology
Fludarabine is a chemotherapy drug used in the treatment of chronic lymphocytic leukemia. It acts at DNA polymerase alpha, ribonucleotide reductase and DNA primase, results in the inhibition of DNA synthesis, and destroys the cancer cells.
Mechanism of Action
Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. The mechanism of action of this antimetabolite is not completely characterized and may be multi-faceted.
Absorption
Not Available
Toxicity
Not Available
Biotrnasformation / Drug Metabolism
Not Available
Contraindications
FLUDARA FOR INJECTION is contraindicated in those patients who are hypersensitive to this drug or its
components.
Drug Interactions
The use of FLUDARA FOR INJECTION in combination with pentostatin is not recommended due to the risk of severe
pulmonary toxicity.
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