Chemisty and Biological Activity
Chemical Formula
C10H13FN5O7P
Chemical Name
[(2R,3R,4S,5R)-5-(6-amino-2-fluoro-purin-9-yl)-3,4-dihydroxy-oxolan-2- yl]methoxyphosphonic acid
Chemical Structure
Molecular Weight
365.212 g/mol
Physical State
Solid
Melting Point
260 oC
Water Solubility
3.53 mg/ml
Isoelectric Point
Not Available
Organisms Affected
Humans and other mammals
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
Not Available
Primary Drug Target
Name | DNA Polymerase alpha (human) | Gene Name | POLA | Synonyms | DNA polymerase alpha catalytic subunit; EC 2.7.7.7 | General Function | Replication, recombination and repair | Specific Function | Polymerase alpha in a complex with DNA primase is a replicative polymerase | Pathway | map00230 Purine metabolism
map00240 Pyrimidine metabolism
map03030 DNA polymerase | Reaction | deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) |
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