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Active ingredient: Fludarabine - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C10H13FN5O7P

Chemical Name

[(2R,3R,4S,5R)-5-(6-amino-2-fluoro-purin-9-yl)-3,4-dihydroxy-oxolan-2- yl]methoxyphosphonic acid

Chemical Structure

Molecular Weight

365.212 g/mol

Physical State

Solid

Melting Point

260 oC

Water Solubility

3.53 mg/ml

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
NameDNA Polymerase alpha (human)
Gene NamePOLA
SynonymsDNA polymerase alpha catalytic subunit; EC 2.7.7.7
General FunctionReplication, recombination and repair
Specific FunctionPolymerase alpha in a complex with DNA primase is a replicative polymerase
Pathwaymap00230 Purine metabolism map00240 Pyrimidine metabolism map03030 DNA polymerase
Reactiondeoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

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