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Active ingredient: Follitropin Beta - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Fertility Agents

Dosage Forms

  • Solution

Brands / Synonyms

Follicle-stimulating hormone beta subunit; Follistim; Follistim (Organon) ; Follitropin beta chain precursor; FSH-B; FSH-beta

Description

Human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which consists of two non-covalently linked, non-identical glycoproteins designated as the - and - subunits. The - and - subunits have 92 and 111 amino acids

Indications

For treatment of female infertility

Pharmacology

Used for the treatment of female infertility, Follitropin beta or follicle stimulating hormone (FSH) stimulates ovarian follicular growth in women who do not have primary ovarian failure. FSH, the active component of Follitropin beta is the primary hormone responsible for follicular recruitment and development.

Mechanism of Action

FSH binds to the follicle stimulating hormone receptor which is a G-coupled transmembrane receptor. Binding of the FSH to its receptor seems to induce phosphorylation and activation of the PI3K (Phosphatidylinositol-3-kinase) and Akt signaling pathway, which is known to regulate many other metabolic and related survival/maturation functions in cells.

Absorption

Not Available

Toxicity

Not Available

Biotrnasformation / Drug Metabolism

Not Available

Contraindications

Not Available

Drug Interactions

Not Available

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