Active ingredient: Hydrochlorothiazide - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C7H8ClN3O4S2

Chemical Name

9-chloro-5,5-dioxo-5^⁶-thia-2,4-diazabicyclo[4.4.0]deca-6,8,10- triene-8-sulfonamide

Chemical Structure

Molecular Weight

297.741 g/mol

Physical State

Solid

Melting Point

274 oC

Water Solubility

0.7 mg/mL

Isoelectric Point

7.9

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target

Name	Thiazide-sensitive sodium-chloride cotransporter
Gene Name	SLC12A3
Synonyms	Solute carrier family 12, member 3; Thiazide-sensitive sodium-chloride cotransporter; Na-Cl symporter
General Function	Inorganic ion transport and metabolism
Specific Function	Electrically silent transporter system. Mediates sodium and chloride reabsorption