Chemisty and Biological Activity
Chemical Formula
C16H16ClN3O3S
Chemical Name
4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)-3-sulfamoyl-benzamide
Chemical Structure
Molecular Weight
365.835 g/mol
Physical State
Solid
Melting Point
161 oC
Water Solubility
75 mg/L
Isoelectric Point
8.8
Organisms Affected
Humans and other mammals
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
Not Available
Primary Drug Target
Name | Potassium voltage-gated channel subfamily KQT member 1 | Gene Name | KCNQ1 | Synonyms | Voltage-gated potassium channel subunit Kv7.1; IKs producing slow voltage-gated potassium channel alpha subunit KvLQT1; KQT-like 1 | General Function | Inorganic ion transport and metabolism | Specific Function | Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea |
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