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Active ingredient: Indapamide - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C16H16ClN3O3S

Chemical Name

4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)-3-sulfamoyl-benzamide

Chemical Structure

Molecular Weight

365.835 g/mol

Physical State

Solid

Melting Point

161 oC

Water Solubility

75 mg/L

Isoelectric Point

8.8

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
NamePotassium voltage-gated channel subfamily KQT member 1
Gene NameKCNQ1
SynonymsVoltage-gated potassium channel subunit Kv7.1; IKs producing slow voltage-gated potassium channel alpha subunit KvLQT1; KQT-like 1
General FunctionInorganic ion transport and metabolism
Specific FunctionProbably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea

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