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Active ingredient: Lenalidomide - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C13H13N3O3

Chemical Name

3-(4-amino-1-oxo-3H-isoindol-2-yl)piperidine-2,6-dione

Chemical Structure

Molecular Weight

259.261 g/mol

Physical State

Solid

Melting Point

Not Available

Water Solubility

Soluble in organic solvent/water mixtures, and buffered aqueous solvents. Lenalidomide is more soluble in organic solvents and low pH solutions. Solubility was significantly lower in less acidic buffers, ranging from about 0.4 to 0.5 mg/mL.

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
NameCOX-2
Gene NamePTGS2
SynonymsProstaglandin G/H synthase 2 precursor; EC 1.14.99.1; Cyclooxygenase- 2; COX-2; Prostaglandin-endoperoxide synthase 2; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; PHS II
Specific FunctionMay have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity
Pathwaymap00590 Prostaglandin and leukotriene metabolism
Reactionarachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O

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