Chemisty and Biological Activity
Chemical Formula
C13H13N3O3
Chemical Name
3-(4-amino-1-oxo-3H-isoindol-2-yl)piperidine-2,6-dione
Chemical Structure
Molecular Weight
259.261 g/mol
Physical State
Solid
Melting Point
Not Available
Water Solubility
Soluble in organic solvent/water mixtures, and buffered aqueous solvents. Lenalidomide is more soluble in organic solvents and low pH solutions. Solubility was significantly lower in less acidic buffers, ranging from about 0.4 to 0.5 mg/mL.
Isoelectric Point
Not Available
Organisms Affected
Humans and other mammals
Phase 1 Metabolising Enzyme (1-st Step of Metabolism)
Not Available
Primary Drug Target
Name | COX-2 | Gene Name | PTGS2 | Synonyms | Prostaglandin G/H synthase 2 precursor; EC 1.14.99.1; Cyclooxygenase- 2; COX-2; Prostaglandin-endoperoxide synthase 2; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; PHS II | Specific Function | May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity | Pathway | map00590 Prostaglandin and leukotriene metabolism | Reaction | arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O |
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