DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Active ingredient: Lisinopril - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula


Chemical Name

1-[6-amino-2-(1-carboxy-3-phenyl-propyl)amino-hexanoyl]pyrrolidine-2- carboxylic acid dihydrate

Chemical Structure

Molecular Weight

405.488 g/mol

Physical State


Melting Point

Not Available

Water Solubility

13 mg/L

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
NameAngiotensin-converting enzyme (ACE)
Gene NameACE
SynonymsAngiotensin-converting enzyme, testis-specific isoform precursor; EC; ACE-T; Dipeptidyl carboxypeptidase I; Kininase II
Specific FunctionConverts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator
ReactionRelease of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II

-- advertisement -- The American Red Cross
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017