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Active ingredient: Meclizine - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Anti-allergic Agents
  • Antiemetics
  • Antihistamines

Dosage Forms

  • Tablet

Brands / Synonyms

Ancolan; Ancolon; Antivert; Antivert/25; Antivert/50; Bonadettes; Bonadoxin; Bonamine; Bonine; Calmonal; Chiclida; Diadril; Dramamine; Dramamine II; Histamethine; Histamethizine; Histametizine; Histametizyne; Itinerol; Longifene; Marex; Meclicot; Meclizine Hcl; Meclozine; Medivert; Monamine; Navicalm; Neo-Istafene; Neo-Suprimal; Neo-Suprimel; Parachloramine; Peremesin; Postafen; Postafene; Ravelon; Sabari; Sea-Legs; Siguran; Subari; Suprimal; Travelon; Veritab; Vibazine; Vomisseis; Vomissels

Indications

For the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness.

Pharmacology

Meclizine, a piperazine-derivative H1-receptor antagonist similar to buclizine, cyclizine, and hydroxyzine, is used as an antivertigo/antiemetic agent. Meclizine is used in the management of nausea, vomiting, and dizziness associated with motion sickness and vertigo in diseases affecting the vestibular apparatus.

Mechanism of Action

Along with its actions as an antagonist at H1-receptors, meclizine also possesses anticholinergic, central nervous system depressant, and local anesthetic effects. Meclizine depresses labyrinth excitability and vestibular stimulation and may affect the medullary chemoreceptor trigger zone.

Absorption

Well absorbed

Toxicity

Symptoms of overdose include drowsiness and anticholinergic effects. LD50=mg/kg (orally in rat).

Biotrnasformation / Drug Metabolism

Hepatic

Contraindications

Meclizine hydrochloride is contraindicated in individuals who have shown a previous hypersensitivity to it.

Drug Interactions

No information provided.

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