Brands, Medical Use, Clinical Data
Drug Category
- Anti-allergic Agents
- Antiemetics
- Antihistamines
Dosage Forms
Brands / Synonyms
Ancolan; Ancolon; Antivert; Antivert/25; Antivert/50; Bonadettes; Bonadoxin; Bonamine; Bonine; Calmonal; Chiclida; Diadril; Dramamine; Dramamine II; Histamethine; Histamethizine; Histametizine; Histametizyne; Itinerol; Longifene; Marex; Meclicot; Meclizine Hcl; Meclozine; Medivert; Monamine; Navicalm; Neo-Istafene; Neo-Suprimal; Neo-Suprimel; Parachloramine; Peremesin; Postafen; Postafene; Ravelon; Sabari; Sea-Legs; Siguran; Subari; Suprimal; Travelon; Veritab; Vibazine; Vomisseis; Vomissels
Indications
For the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness.
Pharmacology
Meclizine, a piperazine-derivative H1-receptor antagonist similar to buclizine, cyclizine, and hydroxyzine, is used as an antivertigo/antiemetic agent. Meclizine is used in the management of nausea, vomiting, and dizziness associated with motion sickness and vertigo in diseases affecting the vestibular apparatus.
Mechanism of Action
Along with its actions as an antagonist at H1-receptors, meclizine also possesses anticholinergic, central nervous system depressant, and local anesthetic effects. Meclizine depresses labyrinth excitability and vestibular stimulation and may affect the medullary chemoreceptor trigger zone.
Absorption
Well absorbed
Toxicity
Symptoms of overdose include drowsiness and anticholinergic effects. LD50=mg/kg (orally in rat).
Biotrnasformation / Drug Metabolism
Hepatic
Contraindications
Meclizine hydrochloride is contraindicated in individuals who have shown a previous hypersensitivity to it.
Drug Interactions
No information provided.
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