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Active ingredient: Megestrol - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula


Chemical Name

17-acetyl-17-hydroxy-6,10,13-trimethyl-2,8,9,11,12,14,15,16-octahydro-1H- cyclopenta[a]phenanthren-3-one

Chemical Structure

Molecular Weight

342.472 g/mol

Physical State


Melting Point


Water Solubility

2 µg/mL (at 37°C for the acetate salt)

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
NameProgesterone Receptor (PR)
Gene NamePGR
SynonymsProgesterone receptor; PR
General FunctionRegulation and cellular proliferation
Specific FunctionThe steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues

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