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Active ingredient: Memantine - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C12H21N

Chemical Name

3,5-dimethyladamantan-1-amine

Chemical Structure

Molecular Weight

179.302 g/mol

Physical State

Solid

Melting Point

258 oC (HCl salt)

Water Solubility

35 mg/mL (HCl salt), 0.9 mg/mL for free base

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
NameGlutamate [NMDA] receptor subunit 3A [Precursor]
Gene NameGRIN3A
SynonymsN-methyl-D-aspartate receptor subtype NR3A; NMDAR-L
General FunctionSignal transduction and cell-cell communication
Specific FunctionNMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism

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