DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Active ingredient: Memantine - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula


Chemical Name


Chemical Structure

Molecular Weight

179.302 g/mol

Physical State


Melting Point

258 oC (HCl salt)

Water Solubility

35 mg/mL (HCl salt), 0.9 mg/mL for free base

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
NameGlutamate [NMDA] receptor subunit 3A [Precursor]
Gene NameGRIN3A
SynonymsN-methyl-D-aspartate receptor subtype NR3A; NMDAR-L
General FunctionSignal transduction and cell-cell communication
Specific FunctionNMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism

-- advertisement -- The American Red Cross
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017