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Active ingredient: Meropenem - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula


Chemical Name

3-[5-(dimethylcarbamoyl)pyrrolidin-2-yl]sulfanyl-6-(1-hydroxyethyl)-4- methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

Chemical Structure

Molecular Weight

383.464 g/mol

Physical State


Melting Point

Not Available

Water Solubility


Isoelectric Point

Not Available

Organisms Affected

Enteric bacteria and other eubacteria

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
NamePenicillin-binding protein 4 precursor
Gene NamedacB
SynonymsPBP-4[Includes: D-alanyl-D- alanine carboxypeptidase; EC; DD-peptidase; DD- carboxypeptidase; D-alanyl-D-alanine-endopeptidase; EC 3.4.99.-; DD- endopeptidase]
General FunctionCell wall/membrane/envelope biogenesis
Specific FunctionNot involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD-endopeptidase reaction
ReactionPreferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine

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