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Active ingredient: Oxytocin - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Anti-tocolytic Agents
  • Labor Induction Agents

Dosage Forms

  • Solution (IV infusion)

Brands / Synonyms

Oxytocin (BAM Biotech); Pitocin; Pitocin (Parke-Davis); Syntocinon; Syntocinon (Sandoz)

Description

Synthetic 9 residue cyclic peptide. The hormone is prepared synthetically to avoid possible contamination with vasopressin (ADH) and other small polypeptides with biologic activity.

Indications

To assist in labor, elective labor induction, uterine contraction induction

Pharmacology

Used to induce labor or to enhance uterine contractions during labor. Uterine motility depends on the formation of the contractile protein actomyosin under the influence of the Ca2+-dependent phosphorylating enzyme myosin light-chain kinase. Oxytocin promotes contractions by increasing the intracellular Ca2+, which in turn activates myosins light chain kinase.. Oxytocin has specific receptors in the muscle llining of the uterus and the receptor concentration increases greatly during pregnancy, reaching a maximum in early labor at term.

Mechanism of Action

Binds the oxytocin receptor which leads to an increase in intracellular calcium levels.

Absorption

Not Available

Toxicity

Not Available

Biotrnasformation / Drug Metabolism

Not Available

Contraindications

Not Available

Drug Interactions

Not Available

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