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Active ingredient: Penicillin V - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Anti-bacterial Agents
  • Penicillins

Dosage Forms

  • Capsule
  • Cream
  • Disc (sustained-release)
  • Drops
  • Drug premix
  • Liquid
  • Lotion
  • Lozenge
  • Ointment
  • Powder
  • Powder for solution
  • Solution
  • Spray
  • Stick
  • Suspension
  • Syrup (sustained-release)
  • Tablet
  • Tablet (enteric-coated)

Brands / Synonyms

Acipen V; Apopen; Beepen-VK; Beromycin; Betapen-Vk; Calcipen; Compocillin V; Crystapen V; Distaquaine V; Eskacillian V; Eskacillin V; Fenacilin; Fenospen; Fenossimetilpenicillina [Dcit]; Fenoximetilpenicilina [Inn-Spanish]; Fenoxypen; Ledercillin Vk; Meropenin; Oracillin; Oratren; Ospen; Pen-Oral; Pen-V; Pen-Vee; Pen-Vee K; Penapar-Vk; Penicillin Phenoxymethyl; Penicillin V; Penicillin V Potassium; Penicillin V [Usan]; Penicillin Vk; Penicillin-Vk; Pfizerpen Vk; Phenocillin; Phenomycilline; Phenopenicillin; Phenoximethylpenicillinum; Phenoxymethyl Penicillin; Phenoxymethylenepenicillinic Acid; Phenoxymethylpenicillin Potassium; Phenoxymethylpenicillinic Acid; Phenoxymethylpenicillinic Acid Potassium Salt; Robicillin; Rocilin; Stabicillin; Uticillin Vk; V-Cil; V-Cillin; V-Cillin K; V-Cylina; V-Cyline; V-Tablopen; Vebecillin; Veetids; Veetids '125'; Veetids '250'; Veetids '500'


For the treatment of mild to moderately severe infections (e.g. dental infection, infections in the heart, middle ear infections, rheumatic fever, scarlet fever, skin infections, upper and lower respiratory tract infections) due to microorganisms


Penicillin V is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Penicillin V has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Penicillin V results from the inhibition of cell wall synthesis and is mediated through Penicillin V binding to penicillin binding proteins (PBPs). Penicillin V is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.

Mechanism of Action

By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Penicillin V inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Penicillin V interferes with an autolysin inhibitor.


25% of the dose given is absorbed,50-60% bioavailable


LD50>1040 mg/kg (Orally in rats with Sodium salt); Nausea, vomiting, stomach pain, diarrhea, and, in rare cases, major motor seizures

Biotrnasformation / Drug Metabolism



A previous hypersensitivity reaction to any penicillin is a contraindication.

Drug Interactions

No information provided.

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