Brands, Medical Use, Clinical Data
Drug Category
- Anti-Inflammatory Agents, Non-Steroidal
- Cyclooxygenase Inhibitors
Dosage Forms
- Capsule
- Suppository
- Tablet
Brands / Synonyms
Apo-Piroxicam; Artroxicam; Baxo; Bruxicam; Caliment; Erazon; Feldene; Flogobene; Geldene; Improntal; Larapam; Pipoxicam; Pirkam; Piroflex; Piroxicam; piroxicam usp
; Reudene; Riacen; Roxicam; Roxiden; Sasulen; Solocalm; Zunden
Indications
For treatment of osteoarthritis and rheumatoid arthritis.
Pharmacology
Piroxicam is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Piroxicam works by reducing hormones that cause inflammation and pain in the body. Piroxicam is used to reduce the pain, inflammation, and stiffness caused by rheumatoid arthritis and osteoarthritis.
Mechanism of Action
The antiinflammatory effect of Piroxicam may result from the reversible inhibition of cyclooxygenase, causing the peripheral inhibition of prostaglandin synthesis. The prostaglandins are produced by an enzyme called Cox-1. Piroxicam blocks the Cox-1 enzyme, resulting into the disruption of production of prostaglandins. Piroxicam also inhibits the migration of leukocytes into sites of inflammation and prevents the formation of thromboxane A2, an aggregating agent, by the platelets.
Absorption
Well absorbed following oral administration.
Toxicity
Symptoms of overdose include drowsiness, nausea, stomach pain, and/or vomiting.
Biotrnasformation / Drug Metabolism
Renal
Contraindications
FELDENE should not be used in patients who have previously exhibited hypersensitivity to it, or in individuals
with the syndrome comprised of bronchospasm, nasal polyps, and angioedema precipitated by aspirin or other
nonsteroidal anti-inflammatory drugs.
Drug Interactions
FELDENE is highly protein bound, and therefore, might be expected to displace other protein-bound drugs. Although
this has not occurred in in vitro studies with coumarin-type anticoagulants, interactions with coumarin-type
anticoagulants have been reported with FELDENE since marketing, therefore, physicians should closely monitor patients
for a change in dosage requirements when administering FELDENE to patients on coumarin-type anticoagulants and other
highly protein-bound drugs.
Plasma levels of piroxicam are depressed to approximately 80% of their normal values when FELDENE is administered
in conjunction with aspirin (3900 mg/day), but concomitant administration of antacids has no effect on piroxicam
plasma levels .
Nonsteroidal anti-inflammatory agents, including FELDENE, have been reported to increase steady state plasma
lithium levels. It is recommended that plasma lithium levels be monitored when initiating, adjusting and
discontinuing FELDENE.
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