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Active ingredient: Pyridostigmine - Brands, Medical Use, Clinical Data

Brands, Medical Use, Clinical Data

Drug Category

  • Antimyasthenics
  • Anticholinergic Agents
  • Cholinesterase Inhibitors
  • Parasympathomimetics

Dosage Forms

  • Liquid
  • Tablet
  • Tablet (extended-release)
  • Syrup

Brands / Synonyms

Mestinon; Pyridine N-Oxide; Pyridostigmine; Pyridostigmine Bromide; Pyridostigmine Bromine; Pyridostigminum; Regonol

Indications

For the treatment of myasthenia gravis.

Pharmacology

Pyridostigmine is a parasympathomimetic and a reversible cholinesterase inhibitor. Pyridostigmine is used to treat muscle weakness in people with myasthenia gravis and to combat the effects of curariform drug toxicity. It also has a military use as a nerve gas antidote.

Mechanism of Action

Pyridostigmine inhibits acetylcholinesterase in the synaptic cleft by competing with acetylcholine for attachment to acetylcholinesterase, thus slowing down the hydrolysis of acetylcholine, and thereby increases efficiency of cholinergic transmission in the neuromuscular junction and prolonges the effects of acetylcholine.

Absorption

Poorly absorbed from the GI tract

Toxicity

Not Available

Biotrnasformation / Drug Metabolism

Hydrolysis by cholinesterases and by liver

Contraindications

Mestinon is contraindicated in mechanical intestinal or urinary obstruction, and particular caution should be used in its administration to patients with bronchial asthma. Care should be observed in the use of atropine for counteracting side effects, as discussed below.

Drug Interactions

No Information Provided.

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