Brands, Medical Use, Clinical Data
Drug Category
- Immunomodulatory Agents
- Antineoplastic Agents
- Anti-infective Agents
Dosage Forms
- Solution (IV Infusion)
- Solution (Subcutaneous Injection)
Brands / Synonyms
Colony-stimulating factor; CSF; GM-CSF; Granulocyte-macrophage colony-stimulating factor precursor; Immunex; Leucomax (Novartis); Leukine; Leukine (Berlex Laboratories Inc)
; Molgramostin
Description
Human, recombinant GM-CSF, expressed in yeast. Glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein.
Indications
For the treatment of cancer and bone marrow transplant
Pharmacology
Sargramostim is used in the treatment of bone marrow transplant recipients or those exposed to chemotherapy an recovering from acut myelogenous leukemia, Leukine or GM-CSF is a hematopoietic growth factor which stimulates the survival, clonal expansion (proliferation) and differentiation of hematopoietic progenitor cells. GM-CSF is also capable of activating mature granulocytes and macrophages. After a bone marrow transplant or chemotherapy, patients have a reduced capacity to produce red and white blood cells. Supplementing them with external sources of GM-CSF helps bring the level of neutrophils back to normal so that they can better fight infections.
Mechanism of Action
Sargramostim binds to the Granulocyte-macrophage colony stimulating factor receptor (GM-CSF-R-alpha or CSF2R) which stimulates a JAK2 STAT1/STAT3 signal transduction pathway. This leads to the production of hemopoietic cells and neutrophils
Absorption
Not Available
Toxicity
Not Available
Biotrnasformation / Drug Metabolism
Not Available
Contraindications
Not Available
Drug Interactions
Not Available
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