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Active ingredient: Tadalafil - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C22H19N3O4

Chemical Name

(6R-trans)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl- pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

Chemical Structure

Molecular Weight

389.404 g/mol

Physical State

Solid

Melting Point

301-302 oC

Water Solubility

Practically insoluble in water

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

CYP3A4

Primary Drug Target
NamecGMP-specific 3',5'-cyclic phosphodiesterase
Gene NamePDE5A
SynonymscGMP-specific 3',5'-cyclic phosphodiesterase; EC 3.1.4.17; CGB-PDE; cGMP-binding cGMP-specific phosphodiesterase
Specific FunctionPlays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'- GMP
Pathwaymap00230 Purine metabolism
Reactionnucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

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