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Active ingredient: Valacyclovir - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C13H20N6O4

Chemical Name

2-[(2-amino-6-oxo-3,9-dihydropurin-9-yl)methoxy]ethyl2-amino-3-methyl- butanoate

Chemical Structure

Molecular Weight

324.336 g/mol

Physical State

Solid

Melting Point

Not Available

Water Solubility

Not Available

Isoelectric Point

Not Available

Organisms Affected

Human herpes virus

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
NameThymidine Kinase
Gene NameTK
SynonymsThymidine kinase; EC 2.7.1.21
Specific FunctionIn latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome
Pathwaymap00240 Pyrimidine metabolism
ReactionATP + thymidine = ADP + thymidine 5'-phosphate

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