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Alcaine (Proparacaine Hydrochloride) - Summary

 
 



ALCAINE SUMMARY

Alcaine®
(proparacaine hydrochloride
ophthalmic solution, USP) 0.5%

ALCAINE® (proparacaine hydrochloride ophthalmic solution, USP) 0.5% is a topical local anesthetic for ophthalmic use.

ALCAINE® ophthalmic solution is indicated for procedures in which a topical ophthalmic anesthetic is indicated: corneal anesthesia of short duration, e.g. tonometry, gonioscopy, removal of corneal foreign bodies, and for short corneal and conjunctival procedures.


See all Alcaine indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Alcaine (Proparacaine)

Effect of proparacaine on tropicamide-induced mydriasis. [1997]
effect of proparacaine on tropicamide-induced pupillary dilation... CONCLUSIONS: Although prior instillation of topical proparacaine produced a

Dilute topical proparacaine for pain relief after photorefractive keratectomy. [1997]
(PRK)... CONCLUSIONS: Dilute (0.05%) topical proparacaine is nonanesthetic and nontoxic,

A comparison of proparacaine and tetracaine eye anesthetics. [1994]
for pain of instillation and duration of activity... CONCLUSION: Proparacaine eye drops cause less pain than tetracaine eye drops upon

Dilution of proparacaine in balanced salt solution reduces pain of anesthetic instillation in the eye. [1994]
the eye to prevent discomfort... CONCLUSIONS: Dilution of P in balanced salt solution to a concentration of 0.03%

A randomised comparison of lidocaine 2% gel and proparacaine 0.5% eye drops in paediatric squint surgery. [2013]
We conducted a randomised trial comparing lidocaine 2% gel with proparacaine 0.5% eye drops in children having elective squint surgery. One hundred and forty children aged between 3 and 14 years were recruited... We conclude that, compared with proparacaine 0.5% eye drops, a single application of lidocaine 2% gel improves peri-operative analgesia and reduces the incidence of postoperative nausea and vomiting in elective paediatric squint surgery.

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Clinical Trials Related to Alcaine (Proparacaine)

Proparacaine and Mydriatic Eye Drops [Terminated]
In this study, we will be evaluating whether premedication with an anesthetic eye drops leads to a decreased sensation of pain when given dilating eye drops prior to eye examinations to evaluate for retinopathy of prematurity in neonatal intensive care unit (NICU) infants.

Proparacaine vs Placebo for Corneal Injuries [Completed]
Introduction: Traumatic injuries to the outer covering of the eye (the cornea) are a common emergency department complaint. They cause significant patient distress including pain, loss of sleep and missed work days. There is currently no accepted, uniform approach to pain management in this patient population. Emergency medicine and ophthalmology texts state that prolonged use of medications that anesthetize the cornea is not recommended. Several recent publications in the ophthalmology literature show that the outpatient use of dilute local anesthesia in patients after eye surgery is a safe and effective method of pain control. In this study, we used Proparacaine (a local anesthetic), in a similar manner, for the outpatient emergency department management of traumatic corneal injuries. Methods: We performed a clinical trial on a sample of adult patients presenting with traumatic corneal injuries to two university affiliated emergency departments in London, Canada. Patients providing signed informed consent to participate in the study received a vial of clear liquid that contained either Proparacaine or plain water (placebo), a pain log, topical antibiotics and oral Acetaminophen (Tylenol) with Codeine for breakthrough pain. Patients were instructed to use the "study drug" on an "as-needed" basis for the next seven days. Patients completed a pain scale describing their discomfort immediately prior to, and five minutes after self-administration of the study drug. All patients were followed closely in an ophthalmology outpatient clinic on Days 1, 3 and 5 after presentation to the emergency department. At the last ophthalmology clinic visit, the patients' pain logs were collected. The protocol was approved by the Research Ethics Board for Health Sciences Research Involving Human Subjects at the University of Western Ontario.

Comparison of Three Different Anesthetic Approaches for Intravitreal Injections [Completed]
92 patients in treatment with intravitreal injections were randomized to 1 of 3 groups: proparacaine 0. 5% drops (Group Drops), proparacaine 0. 5% drops plus subconjunctival lidocaine (Group SC), or 2% lidocaine gel (Group Gel). Patients were asked to score their pain experience using a visual analogue scale (VAS), a scale of 0 to 10, immediately following the injections as well as 10 minutes, 1 hour, 6 hours and 24 hours after. Patients also graded the overall injection experience as Excellent, Very Good, Fair, Poor or Awful. The physician evaluated the patient's eye movement during intravitreal injection in three levels: none or minimal (0), not compromising the injection (1), compromising the injection (2).

Patient Assessment of Topical Anesthetic Effectiveness for Intravitreal Injections [Completed]
There are currently several different commercially available topical eye drops and gels used to reduce eye discomfort (topical anesthetics) during and after eye injections. Dr. Pollack is performing a research study to evaluate three commercially available topical anesthetics (eye numbing treatments) to determine if individuals have a preference for one over the other. The three topical anesthetics being studied are 1) 0. 5% proparacaine hydrochloride (generic, Akorn, Inc), 2) 0. 5% proparacaine hydrochloride (generic, Akorn, Inc) PLUS 4% lidocaine hydrochloride topical solution (generic, Roxane Laboratories), and 3) 3. 5% lidocaine hydrochloride ophthalmic gel (Akten, Akorn, Inc). These eye anesthetics are NOT experimental medications. They are all commercially available topical anesthetics currently used in our offices and their use is widespread among retina specialists throughout the United States. Dr. Pollack will randomly select one topical anesthetic to use and he will ask you to grade your level of pain associated with the injection procedure. Answering these questions should take less than one minute of your time and your identity will NOT be revealed with the results of this study. The results of this study will be used to inform doctors which eye anesthetics patients find most effective for pain control during eye injections.

Pilot Study: A Randomized Trial Of Anesthetic Agents For Intravitreal Injection [Active, not recruiting]
This study is designed to compare four currently used types of anesthesia used for intravitreal injection in order to evaluate the most effective method of anesthesia in reducing pain and discomfort associated with intravitreal injections.

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Reports of Suspected Alcaine (Proparacaine) Side Effects

Drug Abuse (39)Eye Pain (30)Corneal Epithelium Defect (27)Conjunctival Hyperaemia (23)Photophobia (22)Lacrimation Increased (21)Ulcerative Keratitis (15)Keratopathy (14)Hypopyon (13)Visual Acuity Reduced (9)more >>


Page last updated: 2014-11-30

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