Amikin (Amikacin Sulfate) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

All aminoglycosides have the potential to induce auditory, vestibular, and renal toxicity and neuromuscular blockade (see WARNINGS box). They occur more frequently in patients with present or past history of renal impairment, of treatment with other ototoxic or nephrotoxic drugs, and in patients treated for longer periods and/or with higher doses than recommended.

Neurotoxicity-Ototoxicity

Toxic effects on the eighth cranial nerve can result in hearing loss, loss of balance, or both. Amikacin primarily affects auditory function. Cochlear damage includes high frequency deafness and usually occurs before clinical hearing loss can be detected.

Neurotoxicity-Neuromuscular Blockage

Acute muscular paralysis and apnea can occur following treatment with aminoglycoside drugs.

Nephrotoxicity

Elevation of serum creatinine, albuminuria, presence of red and white cells, casts, azotemia, and oliguria have been reported. Renal function changes are usually reversible when the drug is discontinued. As would be expected with any aminoglycoside, reports of toxic nephropathy and acute renal failure have been received during postmarketing surveillance.

Other

In addition to those described above, other adverse reactions which have been reported on rare occasions are skin rash, drug fever, headache, paresthesia, tremor, nausea and vomiting, eosinophilia, arthralgia, anemia, hypotension and hypomagnesemia. Macular infarction sometimes leading to permanent loss of vision has been reported following intravitreous administration (injection into the eye) of amikacin.

REPORTS OF SUSPECTED AMIKIN SIDE EFFECTS / ADVERSE REACTIONS

Possible Amikin side effects / adverse reactions in 52 year old female

Reported by a pharmacist from United Kingdom on 2012-03-16

Patient: 52 year old female

Reactions: Mycobacterium Avium Complex Infection

Adverse event resulted in: hospitalization

Suspect drug(s):
Steroids

Amikin
    Dosage: 600mg for 2 wks
    Start date: 2011-12-01

Other drugs received by patient: Calcium Supplement; Acetaminophen

Possible Amikin side effects / adverse reactions in 65 year old female

Reported by a physician from France on 2012-05-29

Patient: 65 year old female

Reactions: Drug Rash With Eosinophilia and Systemic Symptoms

Suspect drug(s):
Fluconazole (Other Mfr) (Fluconazole)
    Indication: Product Used FOR Unknown Indication

Iron (Iron)
    Indication: Product Used FOR Unknown Indication

Hydroxyzine
    Indication: Product Used FOR Unknown Indication

Iodine (Iodine)
    Indication: Product Used FOR Unknown Indication

Desloratadine
    Indication: Product Used FOR Unknown Indication

Vancomycin
    Indication: Product Used FOR Unknown Indication

Amikin
    Indication: Product Used FOR Unknown Indication

Beta Lactam (Other Beta-Lactam Antibacterials)

Possible Amikin side effects / adverse reactions in 65 year old female

Reported by a physician from France on 2012-06-11

Patient: 65 year old female

Reactions: Skin Test Positive, Drug Rash With Eosinophilia and Systemic Symptoms

Suspect drug(s):
Hydroxyzine
    Indication: Product Used FOR Unknown Indication

Iron (Iron)
    Indication: Product Used FOR Unknown Indication

Desloratadine
    Indication: Product Used FOR Unknown Indication

Fluconazole
    Indication: Product Used FOR Unknown Indication

Amikin
    Indication: Product Used FOR Unknown Indication

Beta Lactam (Other Beta-Lactam Antibacterials)
    Indication: Product Used FOR Unknown Indication

Iodine (Iodine)
    Indication: Product Used FOR Unknown Indication

Vancomycin
    Indication: Product Used FOR Unknown Indication