Ativan (Lorazepam) - Summary

ATIVAN SUMMARY

Ativan (lorazepam), an antianxiety agent, has the chemical formula, 7-chloro-5-(o -chlorophenyl)-1,3-dihydro-3-hydroxy-2 H -1,4-benzodiazepin-2-one.

Ativan (lorazepam) is indicated for the management of anxiety disorders or for the short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic.

The effectiveness of Ativan (lorazepam) in long-term use, that is, more than 4 months, has not been assessed by systematic clinical studies. The physician should periodically reassess the usefulness of the drug for the individual patient.

See all Ativan indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Ativan (Lorazepam)

Final Frontier: Managing Acute Delirium in Last Days of Life
Source: Medscape Hematology-Oncology Headlines [2017.09.28]
Lorazepam plus haloperidol were more effective than haloperidol alone in controlling agitated delirium in patients with advanced cancer.
Medscape Medical News

more news >>

Published Studies Related to Ativan (Lorazepam)

Lorazepam vs diazepam for pediatric status epilepticus: a randomized clinical trial. [2014]
IMPORTANCE: Benzodiazepines are considered first-line therapy for pediatric status epilepticus...

Intravenous promethazine versus lorazepam for the treatment of peripheral vertigo in the emergency department: A double blind, randomized clinical trial of efficacy and safety. [2014]
vertigo reduction compared with lorazepam in ED patients... CONCLUSION: Our study demonstrated the evidence that promethazine is superior to

A comparative study of fixed tapering dose regimen versus symptom-triggered regimen of lorazepam for alcohol detoxification. [2014]
symptom-triggered regimens of lorazepam for alcohol detoxification... CONCLUSION: Symptom-triggered lorazepam treatment for alcohol withdrawal resulted

A double blind randomised comparison of chlordiazepoxide and lorazepam in alcohol withdrawal. [2013]
withdrawal in a double blind design... CONCLUSION: Lorazepam is more effective than chlordiazepoxide in alcohol

RAMPART (Rapid Anticonvulsant Medication Prior to Arrival Trial): a double-blind randomized clinical trial of the efficacy of intramuscular midazolam versus intravenous lorazepam in the prehospital treatment of status epilepticus by paramedics. [2011.10]
Early treatment of prolonged seizures with benzodiazepines given intravenously by paramedics in the prehospital setting has been shown to be associated with improved outcomes. However, an increasing number of Emergency Medical System (EMS) protocols use an intramuscular (IM) route because it is faster and consistently achievable...

more studies >>

Clinical Trials Related to Ativan (Lorazepam)

Lorazepam Sedation for Critically Ill Children [Completed]
This clinical trial is being performed under the Best Pharmaceuticals for Children Act, signed into law in 2002 in order to improve pediatric labeling for off-patent drugs. The purpose of this study is to make sure that lorazepam, when given to children who are very sick in the Intensive Care Unit and who are on a breathing machine, is safe and works as well as a drug called midazolam. Midazolam is already approved by the FDA for this use, but lorazepam is not, even though both drugs are commonly used for sedation.

ADASUVE-Lorazepam Drug-Drug Interaction [Completed]
This study will compare the safety and effects over time for giving both ADASUVE and lorazepam (intramuscular) compared to that of each agent given alone.

Catatonia in Nodding Syndrome and Lorazepam Treatment [Completed]
Nodding Syndrome is an enigmatic neuropsychiatric syndrome affecting children and adolescents mostly in Eastern Africa. The symptoms of Nodding Syndrome and catatonia seem to overlap. The researchers' objectives in this study were to investigate the presence and types of catatonic symptoms in children with Nodding Syndrome and observe their response to one or two doses of lorazepam, the first-line treatment for catatonia.

Intramuscular (IM) Olanzapine Versus IM Haloperidol Plus Lorazepam for Acute Agitation in Schizophrenia [Completed]
The aim of this study was to compare the efficacy and safety of intramuscular 10 mg olanzapine versus intramuscular 5 mg haloperidol plus lorazepam 2 mg in the treatment of acute agitated schizophrenic patients of Taiwanese populations.

Exploring the Effects of Diazepam and Lorazepam [Completed]
Aims :

- exploring lorazepam (0. 038 mg/kg) effects, after a single oral intake, in healthy

volunteers, on the neural correlates of encoding and retrieval of information during a word-stem completion task (implicit memory), using fMRI

- comparing lorazepam effects to diazepam (0. 3 mg/kg)effects

- exploring benzodiazepines effects, after a single oral intake, on the neural correlates

of successful encoding of information within explicit memory using fMRI Hypothesis :

- both diazepam and lorazepam will impair explicit memory performance, but lorazepam only

will impair perceptual priming

- lorazepam and diazepam will modify the normal correlates of information encoding within

explicit memory

- lorazepam only will alter the neural correlates of perceptual priming

more trials >>

Reports of Suspected Ativan (Lorazepam) Side Effects

Amnesia (30),  Chronic Obstructive Pulmonary Disease (28),  Emphysema (23),  Bedridden (21),  Muscle Spasms (16),  Insomnia (13),  Confusional State (12),  Abdominal Pain (11),  Drug Hypersensitivity (11),  Feeling Abnormal (11), more >>

PATIENT REVIEWS / RATINGS / COMMENTS

Ativan review by 37 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		Anxiety
Dosage & duration:		2mg taken as needed for the period of as needed
Other conditions:		N/A
Other drugs taken:		None
		Reported Results
Benefits:		It really help me to cope with the anxiety
Side effects:		Make you tired.
Comments:		Had to take one when not feeling good. Or if anxiety issue to go to the doctor, take one, one hour prior apt

Ativan review by 30 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		Severe Side Effects
		Treatment Info
Condition / reason:		anxiety
Dosage & duration:		1mg at night taken once a day for the period of one weeks
Other conditions:		None
Other drugs taken:		None
		Reported Results
Benefits:		It helped relieve anxiety because it made me sleep. I found that prior to taking this medication, I could not sleep and that I was not eating properly. My overall health was suffering.
Side effects:		It made me so sleepy and sluggish that I could not function properly the next day. While it did resolve sleep issues, it led to many other issues.
Comments:		moderate anxiety.

Ativan review by 67 year old male patient
		Rating
Overall rating:
Effectiveness:		Moderately Effective
Side effects:		Extremely Severe Side Effects
		Treatment Info
Condition / reason:		Anxiety from a reaction
Dosage & duration:		.o5 3 x daily as needed (dosage frequency: 3 x daily) for the period of 10 months then I found out
Other conditions:		None docs looking for cancer... None!
Other drugs taken:		None
		Reported Results
Benefits:		Became addictive .. Docs never told anything that it should only be used very short term, less then two weeks! The then become addictive. Not only that, the told me nothing of side affects, nor tolerance withdrawals, nor, you need to withdraw slowly. These are very dangerous drugs, you my think it helps, but you will pay he'll being on any benzodizapines. If you don,t believe this, go towww.benzo.org read dr (prof) ashton,s Manuel. You will suffer the depth of he'll if you don,t get off these. .
Side effects:		Read the above, no info..
Comments:		No comment.