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Beepen-VK (Penicillin V Potassium) - Summary



brand of
penicillin V potassium
tablets and oral solution

Beepen-VK (penicillin V potassium) is the potassium salt of penicillin V.

Beepen-VK is indicated in the treatment of infections caused by susceptible strains of the designated organisms in the conditions listed below:

Streptococcal infections—mild to moderately severe—of the upper respiratory tract and including scarlet fever and erysipelas.

Pneumococcal infections—mild to moderately severe—of the respiratory tract, including otitis media.

Staphylococcal infections—mild infections of skin and soft tissue (culture and sensitivity tests should be performed).

Fusospirochetosis (Vincent’s infection) of the oropharynx—mild to moderately severe infections.

For prevention of recurrence following rheumatic fever and/or chorea.

Note: Severe pneumonia, empyema, bacteremia, pericarditis, meningitis and arthritis should not be treated with oral penicillins during the acute stage.

Indicated surgical procedures should be performed.

The following infections will usually respond to adequate doses of penicillin V: Streptococcal infections (without bacteremia)—Mild to moderate infections of the upper respiratory tract, scarlet fever and mild erysipelas.

Note: Streptococci in Groups A, C, G, H, L and M are very sensitive to penicillin. Other groups, including group D (enterococcus), are resistant. Pneumococcal infections—Mild to moderately severe infections of the respiratory tract.

Staphylococcal infections (penicillin G-sensitive)—Mild infections of the skin and soft tissue.

Note: Reports indicate an increasing number of strains of staphylococci resistant to penicillin G, emphasizing the need for culture and sensitivity studies in treating suspected staphylococcal infections.

Fusospirochetosis (Vincent’s gingivitis and pharyngitis)—Mild to moderately severe infections of the oropharynx usually respond to therapy with oral penicillin.

Note: Necessary dental care should be accomplished in infections involving the gum tissue.

Medical conditions in which oral penicillin therapy is indicated as prophylaxis: For the prevention of recurrence following rheumatic fever and/or chorea. Prophylaxis with oral penicillin on a continuing basis has proven effective in preventing recurrence of these conditions.

See all Beepen-VK indications & dosage >>


Published Studies Related to Beepen-VK (Penicillin V)

Once-daily amoxicillin versus twice-daily penicillin V in group A beta-haemolytic streptococcal pharyngitis. [2008.06]
BACKGROUND: Rheumatic fever is a preventable chronic disease preceded by group A beta-haemolytic streptococcal (GABHS) pharyngitis. OBJECTIVE: To test the non-inferiority of once-daily (QD) oral amoxicillin to the recommended twice-daily (BID) oral penicillin V in GABHS pharyngitis... CONCLUSION: In this adequately powered study, once-daily oral amoxicillin is not inferior to twice-daily penicillin V for the treatment and eradication of GABHS in children with pharyngitis.

Comparative bioavailability study of two phenoxymethylpenicillin potassium tablet formulations in healthy volunteers. [2007.12]
CONCLUSION: Since the 90% CI for AUC0-t, AUC0-infinity and Cmax ratios were all within the 80 - 125% interval proposed by the US FDA and accepted by ANVISA, it was concluded that the Meracilina formulation (manufactured by AchA(c) S.A.) is bioequivalent to Pen-Ve-Oral (manufactured by Eurofarma) for both the rate and the extent of bioavailability.

Evaluation of phenoxymethylpenicillin treatment of acute otitis media in children aged 2-16. [2007.09]
OBJECTIVE: To study the clinical recovery from acute otitis media (AOM) in children, 2-16 years of age, managed with or without treatment with phenoxymethylpenicillin (PcV)... CONCLUSIONS: Our investigation supports that PcV treatment of AOM does not affect the recovery time or complication rates. PcV provided some symptomatic benefit in the treatment of AOM in otherwise healthy children, aged 2-16 years.

A randomized prospective controlled trial of antibiotic prophylaxis in intraoral bone-grafting procedures: preoperative single-dose penicillin versus preoperative single-dose clindamycin. [2006.05]
In this comparative study, 150 consecutive patients undergoing local intraoral bone grafting randomly received either an oral single dose of 600 mg clindamycin or 2 g of the penicillin phenethicillin 1 h before incision. Primary endpoint was wound infection at the receptor site within 8 weeks of surgery...

Comparison of a two- or three-week regimen and a review of treatment of erythema migrans with phenoxymethylpenicillin. [2006]
BACKGROUND: A longer duration treatment is preferred in erythema migrans (EM) to prevent late complaints. OBJECTIVES: To determine whether 20 (20d-pt) or 14 days (14d-pt) of phenoxymethylpenicillin (PenV) have similar efficacy in treating EM and preventing further sequelae... CONCLUSION: A 2-week treatment regimen of PenV seems to be as effective as a 3-week course with no statistical differences for clinical and serological findings after treatment. Copyright (c) 2006 S. Karger AG, Basel.

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Clinical Trials Related to Beepen-VK (Penicillin V)

Patients Response to Early Switch To Oral:Osteomyelitis Study [Not yet recruiting]
Based on the current literature, investigators hypothesize that patients with osteomyelitis who are treated with the standard approach of intravenous antibiotics for the full duration of therapy will have the same clinical outcomes as patients treated with the experimental approach of intravenous antibiotics with early switch to oral antibiotics. The primary objective of this study is to compare patients with osteomyelitis treated with the standard approach of intravenous antibiotics for the full duration of therapy versus patients treated with intravenous antibiotics with an early switch to oral antibiotics in relation to clinical outcomes at 12 months after discontinuation of antibiotic therapy. Secondary objectives of the study include the evaluation of adverse events related to the use of antibiotics as well as the cost of care evaluated from the hospital perspective.

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Page last updated: 2008-06-22

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