Benicar HCT (Olmesartan Medoxomil / Hydrochlorothiazide) - Summary

BENICAR HCT SUMMARY

BENICAR HCT ^® (olmesartan medoxomil-hydrochlorothiazide) is a combination of an angiotensin II receptor antagonist (AT₁ subtype), olmesartan medoxomil, and a thiazide diuretic, hydrochlorothiazide (HCTZ). Olmesartan medoxomil, a prodrug, is hydrolyzed to olmesartan during absorption from the gastrointestinal tract.

BENICAR HCT ^® is indicated for the treatment of hypertension. This fixed dose combination is not indicated for initial therapy (see DOSAGE AND ADMINISTRATION).

See all Benicar HCT indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Benicar HCT (Olmesartan / Hydrochlorothiazide)

High Blood Pressure (Hypertension) Quiz: Symptoms, Signs & Causes
Source: MedicineNet Facial Nerve Problems Specialty [2017.09.19]
Title: High Blood Pressure (Hypertension) Quiz: Symptoms, Signs & Causes
Category: MedicineNet Quiz
Created: 2/9/2011 12:00:00 AM
Last Editorial Review: 9/19/2017 6:02:11 PM

Pulmonary Hypertension (Symptoms, Treatment Medications, Life Expectancy)
Source: MedicineNet Congenital Heart Disease Specialty [2017.07.26]
Title: Pulmonary Hypertension (Symptoms, Treatment Medications, Life Expectancy)
Category: Diseases and Conditions
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Source: MedicineNet Polycystic Ovary Specialty [2017.03.31]
Title: High Blood Pressure (Hypertension)
Category: Symptoms and Signs
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Portal Hypertension
Source: MedicineNet nitroglycerin Specialty [2016.09.06]
Title: Portal Hypertension
Category: Diseases and Conditions
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Published Studies Related to Benicar HCT (Olmesartan / Hydrochlorothiazide)

Olmesartan/amlodipine vs olmesartan/hydrochlorothiazide in hypertensive patients with metabolic syndrome: the OLAS study. [2011.06]
We studied the effects of treatment with olmesartan/amlodipine and olmesartan/hydrochlorothiazide on inflammatory and metabolic parameters (including new-onset diabetes as a secondary endpoint) in non-diabetic hypertensive patients with metabolic syndrome (MetS)... Both olmesartan-based combinations were effective, but the amlodipine combination resulted in metabolic and anti-inflammatory effects that may have advantages over the hydrochlorothiazide combination.

Effect of delapril/manidipine vs olmesartan/ hydrochlorothiazide combination on insulin sensitivity and fibrinogen in obese hypertensive patients. [2008]
OBJECTIVE: To compare the effect of delapril/manidipine vs olmesartan/hydrochlorothiazide (HCTZ) combination on insulin sensitivity and plasma fibrinogen in obese hypertensive patients... CONCLUSION: In obese hypertensive patients the delapril/manidipine combination but not the olmesartan/HCTZ combination significantly decreased insulin resistance and plasma fibrinogen levels, despite the similar BP lowering efficacy.

Evaluation of antihypertensive therapy with the combination of olmesartan medoxomil and hydrochlorothiazide. [2004.03]
BACKGROUND: Most patients with hypertension require more than one agent to control blood pressure (BP). The purpose of this study was to assess the efficacy and safety of the angiotensin II receptor blocker olmesartan medoxomil in combination with hydrochlorothiazide (HCTZ)... CONCLUSIONS: Olmesartan medoxomil/HCTZ combination therapy produced BP reductions of up to 26.8/21.9 mm Hg and was well tolerated.

A review of olmesartan medoxomil monotherapy: antihypertensive efficacy similar to that of other angiotensin II receptor blocker/hydrochlorothiazide combinations? [2002.11]
Angiotensin II receptor blockers (ARBs) have been available in the United States since 1995...

Olmesartan medoxomil combined with hydrochlorothiazide improves 24-hour blood pressure control in moderate-to-severe hypertension. [2011.11.25]
Abstract Background: 24-hour ambulatory blood pressure monitoring has been shown to be more reliable than conventional measurements for hypertension assessment and the associated increased risk of cardiovascular events. Olmesartan/hydrochlorothiazide combination therapy has demonstrated increased blood pressure lowering over 24 hours compared with the component monotherapies...

more studies >>

Clinical Trials Related to Benicar HCT (Olmesartan / Hydrochlorothiazide)

Drug Interaction Study of Olmesartan in Healthy Chinese Volunteers [Completed]
Hypertension and hyperuricaemia are widespread conditions. There is significant overlap between the two conditions. Serum uric acid (SUA) is currently recognized as a risk factor for cardiovascular disease. Thus, at some point in their therapy, hypertensive patients with hyperuricaemia are likely to require concurrent treatment with anti-hypertensive and hypouricaemic agents. For this reason, it is important to determine whether there are any pharmacokinetic interactions resulting from the concomitant administration of such agents. Olmesartan is an angiotensin II receptor antagonist and effective and well tolerated in the treatment of arterial hypertension. Probenecid is a well-established hypouricaemic agent for the treatment of hyperuricaemia and gout. The goal of this study was to examine the impact of coadministration of probenecid on the pharmacokinetic parameters and tolerability of olmesartan in healthy volunteers.

Efficacy Study of Olmesartan Medoxomil on Coronary Atherosclerosis and Epicardial Adipose Tissue(EAT) [Recruiting]
The purpose of this study is to determine whether olmesartan medoxomil is effective in the treatment of coronary atherosclerosis progression and epicardial adipose tissue(EAT) volume reduction in patients with coronary atherosclerosis detected by coronary CT angiography(CCTA).

Assessment of Efficacy and Safety of Olmesartan Medoxomil in Children and Adolescent Patients With High Blood Pressure [Completed]
This study assesses the efficacy and safety of olmesartan medoxomil in children ages 1-16 with high blood pressure. After a 5-week blinded treatment period of up to 5 weeks participants can continue to take olmesartan medoxomil (OM) for up to an additional 46 weeks.

Efficacy and Safety of LCZ696 in Comparison to Olmesartan in Asian Patients With Essential Hypertension [Completed]
This study will assess the efficacy and safety of multiple doses of LCZ696 compared to olmesartan in Asian patients with essential hypertension

Olmesartan Comparison to Losartan in Hypertensive Subjects [Completed]
This study will evaluate the efficacy and safety of the FDA approved blood pressure medication olmesartan medoxomil compared to the FDA approved medication losartan potassium.

more trials >>

Reports of Suspected Benicar HCT (Olmesartan / Hydrochlorothiazide) Side Effects

Drug Ineffective (29),  Blood Pressure Increased (15),  Hypotension (14),  Overdose (12),  Weight Decreased (10),  Oedema Peripheral (10),  Blood Pressure Systolic Increased (9),  Headache (8),  Drug Administration Error (8),  Dizziness (8), more >>

PATIENT REVIEWS / RATINGS / COMMENTS

Benicar HCT review by 50 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		hypertension
Dosage & duration:		25mg taken 1x/day for the period of 2 years
Other conditions:		stress
Other drugs taken:		none
		Reported Results
Benefits:		lowered blood presssure with no notable side effects.The reduction in blood pressure was immediate with no other bothersome side effects
Side effects:		none -- i was warned that many blood pressure medications have bothersome side-effects including lowered libido, sleep disturbances etc. i suffered no change in any physiological symptoms other than the lowering of my blood pressure
Comments:		Take the medication once per day and take measures to reduce the sources of stress in my life as well as take measures to more efficiently deal with existant daily stress.

Benicar HCT review by 55 year old male patient
		Rating
Overall rating:
Effectiveness:		Moderately Effective
Side effects:		Severe Side Effects
		Treatment Info
Condition / reason:		Hypertension
Dosage & duration:		20 mg/day taken once a day for the period of a couple of months
Other conditions:		Overweight but no other conditions
Other drugs taken:		none
		Reported Results
Benefits:		Blood pressure was decreased initially to where it should have been, and gradually stopped being so effective
Side effects:		Severe rectal pain, beginning around 4 weeks into the treatment. At first there was burning, after bowel movements, then increased to severe burning all the time, then to pain, and finally severe pain (could not sit or lay down). No hemorrhoids, tears, or fisures, but the pain continued, even if no bowel movements for days. Finally stopped taking the medication at the end of August 2009, but the symptoms continue even now (Feb 2010), although not nearly as bad. Now the pain just makes me sit sideways, but at least I can sit and lay down to sleep.
Comments:		I had never been diagnosed with high blood pressure, but had recently gained several pounds because of the double round of steroids I was put on because of a severe skin rash (seasonal allergic reaction). Since we had recently moved I didn't have a PCP yet and the rash on my arms looked like it may have been getting infected, I went to a local emergent care center and saw a doctor there. They took my blood pressure and immediately put me on Benicar HCT, 20 mg, once a day. I took the medication as prescribed until the anal pain got to be too bad. Since going off the medication my BP is a little elevated but I'm reluctant to go back on any meds, especially no one seems to be willing to admit the Benicar caused this problem or is offering any solutions to help it get better.

Benicar HCT review by 55 year old male patient
		Rating
Overall rating:
Effectiveness:		Moderately Effective
Side effects:		Severe Side Effects
		Treatment Info
Condition / reason:		Hypertension
Dosage & duration:		20 mg/day taken once a day for the period of a couple of months
Other conditions:		Overweight but no other conditions
Other drugs taken:		none
		Reported Results
Benefits:		Blood pressure was decreased initially to where it should have been, and gradually stopped being so effective
Side effects:		Severe rectal pain, beginning around 4 weeks into the treatment. At first there was burning, after bowel movements, then increased to severe burning all the time, then to pain, and finally severe pain (could not sit or lay down). No hemorrhoids, tears, or fisures, but the pain continued, even if no bowel movements for days. Finally stopped taking the medication at the end of August 2009, but the symptoms continue even now (Feb 2010), although not nearly as bad. Now the pain just makes me sit sideways, but at least I can sit and lay down to sleep.
Comments:		I had never been diagnosed with high blood pressure, but had recently gained several pounds because of the double round of steroids I was put on because of a severe skin rash (seasonal allergic reaction). Since we had recently moved I didn't have a PCP yet and the rash on my arms looked like it may have been getting infected, I went to a local emergent care center and saw a doctor there. They took my blood pressure and immediately put me on Benicar HCT, 20 mg, once a day. I took the medication as prescribed until the anal pain got to be too bad. Since going off the medication my BP is a little elevated but I'm reluctant to go back on any meds, especially no one seems to be willing to admit the Benicar caused this problem or is offering any solutions to help it get better.