Brevoxyl Gel (Benzoyl Peroxide) - Summary

BREVOXYL GEL SUMMARY

Brevoxyl-4 Gel and Brevoxyl-8 Gel are topical preparations containing benzoyl peroxide 4% and 8%, respectively, as the active ingredient.

Brevoxyl-4 Gel and Brevoxyl-8 Gel are indicated for use in the topical treatment of mild to moderate acne vulgaris. Brevoxyl-4 Gel or Brevoxyl-8 Gel may be used as an adjunct in acne treatment regimens including antibiotics, retinoic acid products, and sulfur/salicylic acid containing preparations.

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NEWS HIGHLIGHTS

Media Articles Related to Brevoxyl Gel (Benzoyl Peroxide)

Health Tip: Four Common Types Of Acne
Source: MedicineNet Acne Specialty [2017.09.20]
Title: Health Tip: Four Common Types Of Acne
Category: Health News
Created: 9/20/2017 12:00:00 AM
Last Editorial Review: 9/20/2017 12:00:00 AM

Acne (Pimples) Quiz: Test Your Medical IQ
Source: MedicineNet Acne Specialty [2017.09.19]
Title: Acne (Pimples) Quiz: Test Your Medical IQ
Category: MedicineNet Quiz
Created: 2/28/2011 4:15:00 PM
Last Editorial Review: 9/19/2017 5:39:39 PM

Skin Quiz: Acne, Dry Skin, Dandruff & More
Source: MedicineNet Acne Specialty [2017.09.19]
Title: Skin Quiz: Acne, Dry Skin, Dandruff & More
Category: MedicineNet Quiz
Created: 10/7/2010 12:00:00 AM
Last Editorial Review: 9/19/2017 5:01:04 PM

Health Tip: Can't Clear Your Acne?
Source: MedicineNet Acne Specialty [2017.08.02]
Title: Health Tip: Can't Clear Your Acne?
Category: Health News
Created: 8/2/2017 12:00:00 AM
Last Editorial Review: 8/2/2017 12:00:00 AM

Acne 101: Types, Best Treatments, Medication, Cystic Acne
Source: MedicineNet isotretinoin Specialty [2017.05.04]
Title: Acne 101: Types, Best Treatments, Medication, Cystic Acne
Category: Slideshows
Created: 10/16/2014 12:00:00 AM
Last Editorial Review: 5/4/2017 12:00:00 AM

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Published Studies Related to Brevoxyl Gel (Benzoyl Peroxide)

The efficacy, safety, and tolerability of adapalene versus benzoyl peroxide in the treatment of mild acne vulgaris: a randomized trial. [2013]
Topical treatments, such as adapalene and benzoyl peroxide (BPO), are popular in mild-to-moderate acne vulgaris... Both topical adapalene 0.1% and BPO 2.5% gels seem safe and effective in mild acne vulgaris, with a marginal tendency toward the former.

Fitzpatrick skin types and clindamycin phosphate 1.2%/benzoyl peroxide gel: efficacy and tolerability of treatment in moderate to severe acne. [2012]
efficacy of acne medications in skin of color... CONCLUSIONS: Acne subjects with Fitzpatrick skin types IV-VI were not found to be

Treatment of moderate to severe acne vulgaris in a Hispanic population: a post-hoc analysis of efficacy and tolerability of clindamycin phosphate 1.2%/benzoyl peroxide 2.5% gel. [2012]
in Hispanics... CONCLUSIONS: Overall efficacy and tolerability with clindamycin phosphate

Efficacy and safety of topical nadifloxacin and benzoyl peroxide versus clindamycin and benzoyl peroxide in acne vulgaris: A randomized controlled trial. [2011.11]
BACKGROUND: Topical therapy with comedolytics and antibiotics are often advocated for mild and moderate severity acne vulgaris. Nadifloxacin, a new fluoroquinolone with anti-Propionibacterium acnes activity and additional anti-inflammatory activity, is approved for use in acne. This randomized controlled assessor blind trial compared the clinical effectiveness and safety of eight weeks therapy of nadifloxacin 1% versus clindamycin 1% as add-on therapy to benzoyl peroxide (2.5%) in mild to moderate grade acne... CONCLUSIONS: Topical nadifloxacin, a new fluoroquinolone is effective, tolerable, and safe for mild o moderate facial acne. Its clinical effectiveness is comparable to clindamycin when used as add-on therapy to benzoyl peroxide.

Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris: a multicentre, randomized, double-blind controlled study. [2011.08]
BACKGROUND: Oral antibiotics in association with a topical retinoid with or without benzoyl peroxide (BPO) are the recommended first-line option in the treatment of moderate to severe acne vulgaris. OBJECTIVES: To evaluate the efficacy and safety of oral lymecycline 300 mg with adapalene 0.1%-BPO 2.5% (A/BPO) fixed-dose gel in comparison with oral lymecycline 300 mg with a vehicle gel in subjects with moderate to severe acne vulgaris... CONCLUSION: These results demonstrate the clinical benefit of combining A/BPO with lymecycline in the treatment of moderate to severe acne vulgaris. (c) 2011 The Authors. BJD (c) 2011 British Association of Dermatologists 2011.

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Clinical Trials Related to Brevoxyl Gel (Benzoyl Peroxide)

Two-week Study to Compare the Tolerance and Irritation Potential of Two Combination Topical Gel Acne Medications [Completed]
This is a single-blind (blinded expert grader), randomized, half-face study being conducted at one clinical site. On 1 side of the face, the subject will apply 1 of the 2 test products, antibiotic and benzoyl peroxide or benzoyl peroxide and adapalene gel and the contra lateral side of the face will remain non-treated to serve as a control. Approximately 25-30 male and female healthy subjects will be randomly assigned to each product

Study Comparing Adapalene and Benzoyl Peroxide Gel 0.1%/2.5% to Epiduo� and Both to a Placebo Control in the Treatment of Acne Vulgaris [Completed]

A Study Comparing Clindamycin 1%/Benzoyl Peroxide 5% Topical Gel to Duac� Topical Gel in the Treatment of Acne Vulgaris [Completed]
The objective of this study is to compare the relative efficacy and safety of the test formulation Clindamycin 1%/Benzoyl Peroxide 5% Topical Gel (Taro Pharmaceuticals Inc.) to the marketed formulation Duac® Topical Gel (Clindamycin 1%/Benzoyl Peroxide 5%) (Stiefel) in the treatment of the inflamed lesions of acne vulgaris. Both the test and reference formulations will also be compared to a placebo formulation to test for superiority.

Efficacy and Tolerance of a Derivative of Salicylic Acid and 5% Benzoyl Peroxide in Facial Acne Vulgaris [Completed]
Acne vulgaris is a frequent inflammatory skin condition involving the pilosebaceous unit and affecting more than 80% of teenagers. Mild to moderate acne vulgaris is usually treated with topical agents such as benzoyl peroxide, retinoids and antibiotics. These treatments can be associated with local tolerance problems and/or antibiotic resistance. Salicylic acid has been shown to be an effective treatment for acne. LHA is a lipophilic hydroxy acid derivative of salicylic acid that has comedolytic and antibacterial properties. The objective of this trial was to compare the efficacy and tolerance of a cream formulation containing 0. 3% LHA (LHA formulation) to a 5% benzoyl peroxide gel.

Study Comparing Clindamycin Phosphate and Benzoyl Peroxide Gel to Acanya® Gel and Both to a Vehicle Control in the Treatment of Acne Vulgaris [Completed]
The objective of this study is to compare the safety and efficacy profiles of Taro Pharmaceutical Inc.'s Clindamycin Phosphate and Benzoyl Peroxide Gel 1. 2%/2. 5% to Acanya® (Clindamycin Phosphate and Benzoyl Peroxide) Gel, 1. 2%/2. 5% and to demonstrate the superior efficacy of the two active formulations over that of the vehicle in the treatment of acne vulgaris.

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