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Campath (Alemtuzumab) - Drug Interactions, Contraindications, Overdosage, etc

 
 



DRUG INTERACTIONS

No formal drug interaction studies have been performed with Campath.

OVERDOSAGE

Across all clinical experience, the reported maximum single dose received was 90 mg. Bone marrow aplasia, infections, or severe infusions reactions occurred in patients who received a dose higher than recommended.

One patient received an 80 mg dose by IV infusion and experienced acute bronchospasm, cough, and dyspnea, followed by anuria and death. Another patient received two 90 mg doses by IV infusion one day apart during the second week of treatment and experienced a rapid onset of bone marrow aplasia.

There is no known specific antidote for Campath. Treatment of overdose consists of drug discontinuation and supportive therapy.

CONTRAINDICATIONS

None

REFERENCES

1 American Association of Blood Banks, America’s Blood Centers, American Red Cross. Circular of Information for the Use of Human Blood and Blood Components. July 2002.

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