DRUG INTERACTIONS
Drug Interactions
In controlled clinical studies, adrenergic beta-receptor
blockers have been frequently administered concomitantly with
CARDENE. The combination is well tolerated.
Beta-Blockers:
Cimetidine increases CARDENE plasma levels. Patients
receiving the two drugs concomitantly should be carefully monitored.
Cimetidine:
Some calcium blockers may increase the concentration of
digitalis preparations in the blood. CARDENE usually does not alter
the plasma levels of digoxin; however, serum digoxin levels should be
evaluated after concomitant therapy with CARDENE is initiated.
Digoxin:
Severe hypotension has been reported during
fentanyl anesthesia with concomitant use of a beta-blocker and a calcium
channel blocker. Even though such interactions were not seen during
clinical studies with CARDENE, an increased volume of circulating fluids
might be required if such an interaction were to occur.
Fentanyl Anesthesia:
Concomitant administration of nicardipine and cyclosporine
results in elevated plasma cyclosporine levels. Plasma concentrations
of cyclosporine should therefore be closely monitored, and its dosage
reduced accordingly, in patients treated with nicardipine.
Cyclosporine:
When therapeutic concentrations of furosemide, propranolol, dipyridamole,
warfarin, quinidine or naproxen were added to human plasma (in vitro),
the plasma protein binding of CARDENE was not altered.
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