Cardura XL (Doxazosin Mesylate) - Summary

CARDURA XL SUMMARY

CARDURA XL (doxazosin mesylate extended release tablets) contains doxazosin mesylate which is a quinazoline compound with the chemical name 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl) piperazine methanesulfonate.

CARDURA XL is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH).

CARDURA XL is not indicated for the treatment of hypertension.

See all Cardura XL indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Cardura XL (Doxazosin)

Benign Prostatic Hyperplasia (Enlarged Prostate) Quiz
Source: MedicineNet Benign Prostatic Hyperplasia Specialty [2017.09.20]
Title: Benign Prostatic Hyperplasia (Enlarged Prostate) Quiz
Category: MedicineNet Quiz
Created: 2/7/2012 3:29:00 PM
Last Editorial Review: 9/20/2017 12:17:12 PM

Enlarged Prostate (BPH, Benign Prostatic Hyperplasia)
Source: MedicineNet Blood In Urine Specialty [2017.05.18]
Title: Enlarged Prostate (BPH, Benign Prostatic Hyperplasia)
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 5/18/2017 12:00:00 AM

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Published Studies Related to Cardura XL (Doxazosin)

Change in sexual function in men with lower urinary tract symptoms/benign prostatic hyperplasia associated with long-term treatment with doxazosin, finasteride and combined therapy. [2014]
Inventory during 4 years... CONCLUSIONS: This study significantly extends understanding of the effects of

Long-term effects of doxazosin, finasteride, and combination therapy on quality of life in men with benign prostatic hyperplasia. [2013]
International Prostate Symptom Score [IPSS]-QoL) over 4 years... CONCLUSIONS: QoL of men treated with doxazosin, finasteride, and

Long-term effects of doxazosin, finasteride and combination therapy on quality of life in men with benign prostatic hyperplasia. [2013]
International Prostate Symptom Score-QoL) during 4 years... CONCLUSIONS: The quality of life of men treated with doxazosin, finasteride, and

Effect of doxazosin gastrointestinal therapeutic system 4 mg vs tamsulosin 0.2 mg on nocturia in Chinese men with lower urinary tract symptoms: a prospective, multicenter, randomized, open, parallel study. [2011.09]
OBJECTIVE: To compare the efficacy of the doxazosin gastrointestinal therapeutic system (doxazosin-GITS) 4 mg and tamsulosin 0.2 mg on nocturia in Chinese men with lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH)... CONCLUSION: In Chinese patients with LUTS/BPH, doxazosin-GITS is slightly better than tamsulosin in reducing the frequency of nocturia. Copyright (c) 2011 Elsevier Inc. All rights reserved.

Tamsulosin and doxazosin as adjunctive therapy following shock-wave lithotripsy of renal calculi: randomized controlled trial. [2011.08.12]
Alpha-blockers have been established as medical expulsive therapy for urolithiasis. We aimed to assess the effect of tamsulosin and doxazosin as adjunctive therapy following SWL for renal calculi... The side-effects of these agents are common and should be weighted against the benefits of their usage.

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Clinical Trials Related to Cardura XL (Doxazosin)

The Effects of Doxazosin on the Cardiovascular and Subjective Effects of Cocaine [Completed]
The purpose of the study is to asses the potential interactions between intravenous cocaine and doxazosin in cocaine dependent volunteers who are not seeking treatment. The study will evaluate the effects of doxazosin on the cardiovascular and subjective effects of cocaine in a human laboratory study.

Pharmacological Interaction Between Doxazosin and Methylenedioxymethamphetamine (MDMA) [Completed]
The purpose of this study is to determinate the effect of a pre-treatment with doxazosin, a alpha1-adrenergic receptor blocker, on the pharmacodynamics and pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"). The investigators hypothesize that doxazosin will attenuate the cardiovascular and subjective response to MDMA.

A Pilot Study to Assess the Effects of Doxazosin on Polysomnography in PTSD [Recruiting]
This study will assess the effects of the medication doxazosin on sleep in men and women with PTSD. Sleep will be measured objectively at home using a portable sleep recorder and wrist actigraphy.

Does Doxazosin Attenuate Stress-induced Smoking and Improve Clinical Outcomes? [Active, not recruiting]
The purpose of this study is to examine whether doxazosin will attenuate the ability of stress to precipitate smoking lapse behavior in treatment seeking daily smokers. Participants will participate in a smoking cessation attempt after the laboratory sessions.

Doxazosin for PTSD and Alcohol Use Disorder [Not yet recruiting]
The study will test the efficacy of doxazosin, a long-acting and selective alpha-1 adrenergic antagonist, as compared to placebo in reducing PTSD symptomatology and alcohol use severity.

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PATIENT REVIEWS / RATINGS / COMMENTS

Cardura XL review by 65 year old male patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		BPH
Dosage & duration:		2 mg taken 1/day for the period of still do
Other conditions:		none
Other drugs taken:		Flomax before switching to Cardura
		Reported Results
Benefits:		Increased urinary flow w/o the side effects of Flomax (decreased erectile strength). Available strengths are more varied with Cardura, thus effectiveness can be achieved with minimal dosage.
Side effects:		None with Cardura. I switched from Flomax because the minimum dosage of 4 mg reduced libido and erectile strength. Not completely, but "half-mast" so to speak.
Comments:		1 2mg tablet at night. Must be taken at the same time as effects last only 22-24 hours. This medication is also used to lower blood pressure, but at the dosage I am taking, my BP remains in the normal range of 75-80.