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Cardura (Doxazosin Mesylate) - Summary



CARDURA® (doxazosin mesylate) is a quinazoline compound that is a selective inhibitor of the alpha1 subtype of alpha adrenergic receptors.

CARDURA® (doxazosin mesylate) is indicated for the following:

A. Benign Prostatic Hyperplasia (BPH)

CARDURA is indicated for the treatment of both the urinary outflow obstruction and obstructive and irritative symptoms associated with BPH: obstructive symptoms (hesitation, intermittency, dribbling, weak urinary stream, incomplete emptying of the bladder) and irritative symptoms (nocturia, daytime frequency, urgency, burning). CARDURA may be used in all BPH patients whether hypertensive or normotensive. In patients with hypertension and BPH, both conditions were effectively treated with CARDURA monotherapy. CARDURA provides rapid improvement in symptoms and urinary flow rate in 66–71% of patients. Sustained improvements with CARDURA were seen in patients treated for up to 14 weeks in double blind studies and up to 2 years in open-label studies.

B. Hypertension

CARDURA (doxazosin mesylate) is also indicated for the treatment of hypertension. CARDURA may be used alone or in combination with diuretics, beta-adrenergic blocking agents, calcium channel blockers or angiotensin-converting enzyme inhibitors.

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Published Studies Related to Cardura (Doxazosin)

Change in sexual function in men with lower urinary tract symptoms/benign prostatic hyperplasia associated with long-term treatment with doxazosin, finasteride and combined therapy. [2014]
Inventory during 4 years... CONCLUSIONS: This study significantly extends understanding of the effects of

Long-term effects of doxazosin, finasteride, and combination therapy on quality of life in men with benign prostatic hyperplasia. [2013]
International Prostate Symptom Score [IPSS]-QoL) over 4 years... CONCLUSIONS: QoL of men treated with doxazosin, finasteride, and

Long-term effects of doxazosin, finasteride and combination therapy on quality of life in men with benign prostatic hyperplasia. [2013]
International Prostate Symptom Score-QoL) during 4 years... CONCLUSIONS: The quality of life of men treated with doxazosin, finasteride, and

Effect of doxazosin gastrointestinal therapeutic system 4 mg vs tamsulosin 0.2 mg on nocturia in Chinese men with lower urinary tract symptoms: a prospective, multicenter, randomized, open, parallel study. [2011.09]
OBJECTIVE: To compare the efficacy of the doxazosin gastrointestinal therapeutic system (doxazosin-GITS) 4 mg and tamsulosin 0.2 mg on nocturia in Chinese men with lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH)... CONCLUSION: In Chinese patients with LUTS/BPH, doxazosin-GITS is slightly better than tamsulosin in reducing the frequency of nocturia. Copyright (c) 2011 Elsevier Inc. All rights reserved.

Tamsulosin and doxazosin as adjunctive therapy following shock-wave lithotripsy of renal calculi: randomized controlled trial. [2011.08.12]
Alpha-blockers have been established as medical expulsive therapy for urolithiasis. We aimed to assess the effect of tamsulosin and doxazosin as adjunctive therapy following SWL for renal calculi... The side-effects of these agents are common and should be weighted against the benefits of their usage.

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Clinical Trials Related to Cardura (Doxazosin)

The Effects of Doxazosin on the Cardiovascular and Subjective Effects of Cocaine [Completed]
The purpose of the study is to asses the potential interactions between intravenous cocaine and doxazosin in cocaine dependent volunteers who are not seeking treatment. The study will evaluate the effects of doxazosin on the cardiovascular and subjective effects of cocaine in a human laboratory study.

Pharmacological Interaction Between Doxazosin and Methylenedioxymethamphetamine (MDMA) [Completed]
The purpose of this study is to determinate the effect of a pre-treatment with doxazosin, a alpha1-adrenergic receptor blocker, on the pharmacodynamics and pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"). The investigators hypothesize that doxazosin will attenuate the cardiovascular and subjective response to MDMA.

A Pilot Study to Assess the Effects of Doxazosin on Polysomnography in PTSD [Recruiting]
This study will assess the effects of the medication doxazosin on sleep in men and women with PTSD. Sleep will be measured objectively at home using a portable sleep recorder and wrist actigraphy.

Does Doxazosin Attenuate Stress-induced Smoking and Improve Clinical Outcomes? [Active, not recruiting]
The purpose of this study is to examine whether doxazosin will attenuate the ability of stress to precipitate smoking lapse behavior in treatment seeking daily smokers. Participants will participate in a smoking cessation attempt after the laboratory sessions.

Doxazosin for PTSD and Alcohol Use Disorder [Not yet recruiting]
The study will test the efficacy of doxazosin, a long-acting and selective alpha-1 adrenergic antagonist, as compared to placebo in reducing PTSD symptomatology and alcohol use severity.

more trials >>

Reports of Suspected Cardura (Doxazosin) Side Effects

Syncope (14)Blood Pressure Increased (11)Hypotension (10)Dyspnoea (9)Drug Ineffective (8)Headache (8)Cerebrovascular Accident (7)Prostatic Disorder (7)Anxiety (7)Hypertension (7)more >>


Based on a total of 1 ratings/reviews, Cardura has an overall score of 8. The effectiveness score is 8 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.

Cardura review by 49 year old male patient

Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
Treatment Info
Condition / reason:   Problems with my prostate
Dosage & duration:   2mg taken daily for the period of 45 days
Other conditions:   none
Other drugs taken:   Prevacid
Reported Results
Benefits:   Reduced prostate pain.
Side effects:   None that I am aware of.
Comments:   I took this medication to reduce pain I was experiencing with my prostate. It took about two to three weeks after which the pain was significantly reduced. I was also experiencing a sense of tightness in this area that it eliminated.

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Page last updated: 2014-11-30

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