Catapres (Clonidine Hydrochloride) - Summary

CATAPRES SUMMARY

CATAPRES-TTS^® (clonidine) is a transdermal system providing continuous systemic delivery of clonidine for 7 days at an approximately constant rate. Clonidine is a centrally acting alpha-agonist hypotensive agent.

Catapres-TTS transdermal therapeutic system is indicated in the treatment of hypertension. It may be employed alone or concomitantly with other antihypertensive agents.

See all Catapres indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Catapres (Clonidine)

Clonidine Maintenance Prolongs Opioid Abstinence and Decouples Stress From Craving in Daily Life: A Randomized Controlled Trial With Ecological Momentary Assessment. [2015]
CONCLUSIONS: Clonidine, a readily available medication, is useful in opioid

A randomized feasibility trial of clonidine to reduce perioperative cardiac risk in patients on chronic beta-blockade: the EPIC study. [2014]
chronic beta-blockade... CONCLUSION: This pilot randomized trial confirmed the feasibility, safety, and

Effect of oral low dose clonidine premedication on postoperative pain in patients undergoing abdominal hysterectomy: a randomized placebo controlled clinical trial. [2013]
CONCLUSION: A single oral 100 microg dose of clonidine administered 2 hours

Prophylactic midazolam and clonidine for emergence from agitation in children after emergence from sevoflurane anesthesia: a meta-analysis. [2013]
sevoflurane anesthesia... CONCLUSIONS: This meta-analysis suggests that prophylactic administration of

Clonidine improved laboratory-measured decision-making performance in abstinent heroin addicts. [2012]
BACKGROUND: Impulsivity refers to a wide spectrum of actions characterized by quick and nonplanned reactions to external and internal stimuli, without taking into account the possible negative consequences for the individual or others, and decision-making is one of the biologically dissociated impulsive behaviors...

more studies >>

Clinical Trials Related to Catapres (Clonidine)

The Effect of Clonidine-enhanced Sedation on Delirium in Ventilated Critically Ill Patients [Not yet recruiting]
Rationale: Delirium is highly prevalent in the ICU. GABA-ergic anaesthetics may provoke delirium. Alpha-2-adrenergic agonists may lead to a reduction of the total amount of GABA-ergic anaesthetics and reduction of delirium. There are no large studies proving that this therapy is effective and safe. Objective: The objective of this study is to compare the effect of clonidine with placebo on the occurrence and duration of delirium in mechanically ventilated ICU patients. Study design: Prospective randomised double-blind placebo controlled intervention study in 115 patients. Study population: All patients >18 years old, intubated mechanically ventilated and sedated at inclusion. Intervention: Clonidine infusion of 0,25 mcg/kg/h added to the standard sedation regimen. Comparison: NaCl 0,9 % infusion as placebo. Main study parameters/endpoints: The main study parameter is the total number of awake and delirium-free observation periods the first 7 days after randomisation. An observation period is a nursing shift of 8 hours.

Bioequivalence of Two Transdermal Clonidine Administrations in Healthy Volunteers [Completed]
To establish the bioequivalence and adhesion properties of transdermal clonidine prepared with Oppanol® brands of polyisobutylene (PIB) vs. transdermal clonidine prepared with VistanexTM brands of polyisobutylene (PIB) in healthy male and female volunteers.

Effect of Intrathecal Clonidine in Hypertensive Subjects With Poorly Controlled Blood Pressure [Completed]
The purpose of this study is to determine the acute efficacy of intrathecal clonidine to reduce blood pressure in hypertensive subjects with poor blood pressure control and describe its effects on cardiovascular function.

Epidural Clonidine for Lumbosacral Radiculopathy [Terminated]
This was a randomized, blinded study of transforaminal epidural injection of clonidine versus a similar injection of corticosteroid for acute lumbosacral radiculopathy. The hypothesis was that clonidine will be as effective as steroid for this condition.

Ropivacaine With Clonidine For Pediatric Rectus Sheath Blocks- The Magic Combination [Not yet recruiting]
Background: Millions of pediatric patients undergo laparoscopic surgeries every year and many of them suffer significant pain and anxiety. Patient's anxiety correlates with the severity of pain and effective postoperative analgesia is necessary for optimal recovery. Single injections ultrasound guided rectus sheath blocks provide satisfactory postoperative analgesia after pediatric laparoscopic appendectomy, however they are short lived. Searching for a blocking agent that last long enough to outlast pain and has minimal side effects is a difficult task. Using a combination of drugs yielded mixed results. Few pediatric studies showed at best a weak trend in favor of clonidine prolonging analgesia after some blocks, but anxiolytic properties of clonidine were not investigated. This study will compare rectus sheath ropivacaine blocks with ropivacaine and clonidine blocks. Methods: One hundred pediatric patients (10-17 years old) scheduled for laparoscopic appendectomy will be double blinded and randomized to the two treatment groups: the Ropivacaine Group will receive ropivacaine 0. 5% (10 ml) injected bilaterally in the posterior rectus sheath, at the umbilicus location, and Ropivacaine Clonidine Group will receive ropivacaine 0. 5% (10 ml) and clonidine (2mcg/kg). Post-operative analgesia will be provided with ketorolac and acetaminophen around the clock, and morphine, or/and oxycodone as needed. The primary aim is to determine if ropivacaine combined with clonidine prolongs duration of paresthesia. The secondary aims are to determine if the use of clonidine decreases anxiety level, prolongs duration of analgesia, and decreases pain severity at umbilicus laparoscopic site, reduces the need for analgesics, improves satisfaction with pain control, and is associated with complications such as oversedation, hypotension, and bradycardia. Conclusions: Every hour of excellent analgesia count and a prolongation of block duration by at least 50% is clinical relevant. The investigators hypothesize that rectus sheath injections with ropivacaine and clonidine offer improved pain management compared to ropivacaine alone.

more trials >>

Reports of Suspected Catapres (Clonidine) Side Effects

Hypertension (8),  Weight Decreased (7),  Hair Texture Abnormal (7),  DRY Mouth (7),  Decreased Appetite (7),  Hypotension (7),  Anxiety (7),  Drug Ineffective (6),  Headache (6),  Blood Pressure Increased (6), more >>

PATIENT REVIEWS / RATINGS / COMMENTS

Catapres review by 52 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		high blood pressure
Dosage & duration:		one tab twice daily taken twice daily for the period of since 2007 to current
Other conditions:		hot flashes
Other drugs taken:		lisinopril/hctz 20-12.5 tab
		Reported Results
Benefits:		(clonidine)It assisted in lowering my blood pressure by causing me to have a more voluminous (not more frequent)urination,when urged.Also,it aided in- depressing my agonizing hot flashes.They came at sequential intervals at time of menses and would last in that manner until completion of menses.Thereafter,they were intermitten daily.
Side effects:		If this is the side effect.It would be, soon after taking the meds,There is a timed-released drowsy effect that occurs,within a matter of 15-20 minutes.This is the only so-called side effect that I've experienced.But,I guess,it is a matter of where you are and what's on your agenda during this side-effect.
Comments:		I'm not completely sure what to write here,that would consist of fifty words.I take (Clonidine)-0.1mg 1 tab twice daily and (Lisinopril/HCTZ)-20mgs.12.5 1tab,twice daily.I've learned to take them with food.Earlier,when introduced to these meds,upon attending a Drs. appointment and having my blood pressure checked,the reading would be high and I felt no internal or external symptoms.The inquiry would be have you taken your meds? and I had.So,it was suggested that I try administering them with food.Thereafter,no more high readings and entered a normalized phase.

Catapres review by 59 year old female patient
		Rating
Overall rating:
Effectiveness:		Ineffective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		Hot Flashes
Dosage & duration:		0.1 mg taken 1x a day at bedtime for the period of Once
Other conditions:		Hypothyroidism
Other drugs taken:		Synthroid
		Reported Results
Benefits:		It was supposed to stop the hot flashes that were keeping me awake at night.
Side effects:		Left me extremely sleepy the next day to the point I had to lay down an hour after I got up and I noticed no real difference in the hot flashes.
Comments:		I wanted to stop hot flashes without going on HRT medication. My doctor recommended trying Clonidine

Catapres review by 59 year old female patient
		Rating
Overall rating:
Effectiveness:		Ineffective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		Hot Flashes
Dosage & duration:		0.1 mg taken 1x a day at bedtime for the period of Once
Other conditions:		Hypothyroidism
Other drugs taken:		Synthroid
		Reported Results
Benefits:		It was supposed to stop the hot flashes that were keeping me awake at night.
Side effects:		Left me extremely sleepy the next day to the point I had to lay down an hour after I got up and I noticed no real difference in the hot flashes.
Comments:		I wanted to stop hot flashes without going on HRT medication. My doctor recommended trying Clonidine