SUMMARY
CAVERJECT contains alprostadil as the naturally occurring form of prostaglandin E1.
CAVERJECT (CAVERJECT IMPULSE, CAVERJECT Sterile Powder, and CAVERJECT Injection) is indicated for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology.
Intracavernosal CAVERJECT is also indicated as an adjunct to other diagnostic tests in the diagnosis of erectile dysfunction.
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NEWS HIGHLIGHTS
Published Studies Related to Caverject Impulse (Alprostadil)
Alprostadil infusion in patients with dry age related macular degeneration: a
randomized controlled clinical trial. [2013]
alprostadil infusion in patients with dAMD... CONCLUSION: A numerical treatment effect in favor of alprostadil was visible,
Efficacy and safety of alprostadil cream for the treatment of female sexual
arousal disorder: a double-blind, placebo-controlled study in chinese population. [2008]
of a novel alprostadil topical cream for the treatment of FSAD... CONCLUSION: These results demonstrated that the application of topical
[Intraurethrally applicated alprostadil for the treatment of organic erectile dysfunction in practice: a multicenter clinical monitoring study (noninterventional investigation)] [2007]
In a multicenter clinical monitoring study (observation of use investigation according to 67.6 of the German Drug Law), which was conducted between 2003 and 2005 in 105 urological practices in 314 patients with organic erectile dysfunction (ED), efficacy, safety, convenience and acceptance of intraurethral administered alprostadil (CAS 745-65-3; MUSE - Medicated Urethral System for Erection) was studied...
An integrated analysis of alprostadil topical cream for the treatment of erectile
dysfunction in 1732 patients. [2006]
erectile dysfunction (ED)... CONCLUSIONS: Topical alprostadil cream significantly improves ED in a broad range
Comparison between iloprost and alprostadil in the treatment of Raynaud's phenomenon. [2004]
OBJECTIVE: The prostanoids iloprost and alprostadil are widely used to treat ischaemic changes in patients with Raynaud's phenomenon (RP), but the optimal regimen is poorly defined. We evaluated whether there are differences between iloprost and alprostadil, in terms of either clinical efficacy or of laboratory data, with the aim of assisting in the treatment of connective tissue disease (CTD)-associated RP... CONCLUSION: Iloprost and alprostadil were both of benefit in CTD-associated RP, without significant differences in either clinical efficacy or circulating markers. However, ease of handling and the lower price favours alprostadil.
Clinical Trials Related to Caverject Impulse (Alprostadil)
The Use of Prostaglandin E1 in Head and Neck Microsurgery [Recruiting]
Prostaglandin E1 (PGE1 )has been shown to have vasodilatation and anti-thrombosis effects,
so it is used by some surgeons after microsurgery to keep the patency of the anastomosed
small vessels. However, PGE 1 may also causes some complications, like pleural effusion or
deep vein thrombosis. Therefore, it remains uncertain whether a routine use of PGE 1 after
head and neck microsurgery is justified. We aim to test the hypothesis that PGE 1 increases
postoperative vessel patency rate in patients undergoing head and neck microsurgery, with a
comparable complication rate as the control group.
Protective Effect of Lipo-PGE1 on Myocardial Injury Following Percutaneous Coronary Intervention [Not yet recruiting]
we hypothesized that periprocedural treatment with intravenous lipo-PGE1 may reduce
myocardial injury and improve clinical outcomes in patients undergoing PCI.
Prostaglandin E1 in Outpatients With Intermittent Claudication [Completed]
Investigate, under outpatient conditions, both the effect of 4 weeks of daily treatment with
Prostaglandin E1 and that of 4 weeks of interval treatment (two infusions per week) on the
pain-free walking distance in patients with Intermittent Claudication.
Alprostadil in Maculopathy Study (AIMS) [Terminated]
Alprostadil in Peripheral Arterial Occlusive Disease (PAOD) Stage IV [Completed]
The study is to confirmatorily show a superior effect of Alprostadil compared to placebo on
the rate of complete healing of ischemic necroses and ulcerations as well as on the
frequency and height of major amputations in patients suffering from PAOD stage IV.
Reports of Suspected Caverject Impulse (Alprostadil) Side Effects
Drug Ineffective (3),
Erectile Dysfunction (3),
Erection Increased (3),
Urethral Stenosis (2),
Gastritis Erosive (2),
Gastric Ulcer (2),
Anorgasmia (2),
Bladder Diverticulum (2),
Urinary Retention (2),
Urethrotomy (2), more >>
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