Celestone (Betamethasone) - Description and Clinical Pharmacology

brand of betamethasone
Oral Solution, USP

PRODUCT INFORMATION

DESCRIPTION

CELESTONE^® Oral Solution, for oral administration, contains 0.6 mg betamethasone in each 5 mL. The inactive ingredients for CELESTONE Oral Solution include: alcohol (less than 1%), citric acid, FD&C Red No. 40, FD&C Yellow No. 6, flavors, propylene glycol, sodium benzoate, sodium chloride, sorbitol, sugar, and water.

The formula for betamethasone is C₂₂H₂₉FO₅ and it has a molecular weight of 392.47. Chemically, it is 9-fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione and has the following structure:

Betamethasone is a white to practically white, odorless crystalline powder. It melts at about 240°C with some decomposition. Betamethasone is sparingly soluble in acetone, alcohol, dioxane, and methanol; very slightly soluble in chloroform and ether; and is insoluble in water.

CLINICAL PHARMACOLOGY

Glucocorticoids, naturally occurring and synthetic, are adrenocortical steroids that are readily absorbed from the gastrointestinal tract.

Naturally occurring glucocorticoids (hydrocortisone and cortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states. Their synthetic analogs, such as betamethasone, are primarily used for their anti-inflammatory effects in disorders of many organ systems. A derivative of prednisolone, betamethasone has a 16β-methyl group that enhances the anti-inflammatory action of the molecule and reduces the sodium- and water-retaining properties of the fluorine atom bound at carbon 9.

Celestone (Betamethasone) - Description and Clinical Pharmacology

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CLINICAL PHARMACOLOGY